DEFB108B
Defensin Beta 108B
Gene Information Card
| Symbol | DEFB108B |
|---|---|
| Full Name | Defensin Beta 108B |
| Gene Type | protein-coding |
| Chromosomal Location | 6p12.3 |
| NCBI Gene ID | 100422541 ncbi.nlm.nih.gov/gene/100422541 |
| Ensembl ID | ENSG00000205542 |
| UniProt ID | Q5JQC9 |
| OMIM ID | None |
| HGNC ID | HGNC:40010 |
| Aliases | DEFB-108B, DEFB108, DEFB108B1 |
Description
DEFB108B (Defensin Beta 108B) is a protein-coding gene located on chromosome 6p12.3. It belongs to the beta-defensin family of antimicrobial peptides, which play a role in innate immunity by disrupting microbial membranes. The gene is part of a cluster of defensin genes on chromosome 6.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| None reported | No known disease association | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.0 | Not detected |
| Skin | 0.0 | Not detected |
| Lung | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| No data available |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported variants |
Mutation functional classification
Loss of Function (LOF)
No data
Gain of Function (GOF)
No data
Dominant Negative (DN)
No data
View complete mutation data：
Protein Summary
The DEFB108B protein is a predicted beta-defensin antimicrobial peptide. Its exact function has not been experimentally characterized, but it is presumed to contribute to host defense against pathogens.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DEFB108B Knockout HEK293 Cell Line | EDJ-KQ11510 | Human | 245911 | Details Get a Quote |
| DEFB108B Knockout HeLa Cell Line | EDJ-KQ59212 | Human | 245911 | Details Get a Quote |
| DEFB108B Knockout A-549 Cell Line | EDJ-KQ67680 | Human | 245911 | Details Get a Quote |
| DEFB108B Knockout HCT 116 Cell Line | EDJ-KQ76064 | Human | 245911 | Details Get a Quote |
