DDTL (D-Dopachrome Tautomerase Like)
A pseudogene related to the D-dopachrome tautomerase gene family, with limited functional characterization.
Gene Information Card
| Symbol | DDTL |
|---|---|
| Full Name | D-dopachrome tautomerase like |
| Gene Type | pseudogene |
| Chromosomal Location | 22q11.21 |
| NCBI Gene ID | 100037417 ncbi.nlm.nih.gov/gene/100037417 |
| Ensembl ID | ENSG00000215647 |
| UniProt ID | N/A (pseudogene) |
| OMIM ID | N/A |
| HGNC ID | HGNC:33823 |
| Aliases | MGC129935, MGC129936 |
Description
DDTL (D-dopachrome tautomerase like) is a pseudogene located on chromosome 22q11.21. It is considered a processed pseudogene derived from the DDT (D-dopachrome tautomerase) gene. No protein product is expected, and its biological function, if any, remains unclear. It is not associated with any known disease in current databases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No known disease associations | N/A | No evidence in OMIM, ClinVar, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| No expression data available | N/A | Pseudogene; no protein expression |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| No expression data available | N/A | Pseudogene; no protein expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported mutations | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
Not applicable (pseudogene)
Gain of Function (GOF)
Not applicable (pseudogene)
Dominant Negative (DN)
Not applicable (pseudogene)
View complete mutation data：
Protein Summary
DDTL is a pseudogene and does not encode a functional protein. It is homologous to the D-dopachrome tautomerase gene but contains disruptions that prevent translation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DDTL Knockout HEK293 Cell Line | EDJ-KQ13113 | Human | 100037417 | Details Get a Quote |
| DDTL Knockout A-549 Cell Line | EDJ-KQ42420 | Human | 100037417 | Details Get a Quote |
| DDTL Knockout HCT 116 Cell Line | EDJ-KQ42421 | Human | 100037417 | Details Get a Quote |
| DDTL Knockout HeLa Cell Line | EDJ-KQ42422 | Human | 100037417 | Details Get a Quote |
