DCP1B
Decapping mRNA 1B, a key regulator of mRNA decay
Gene Information Card
| Symbol | DCP1B |
|---|---|
| Full Name | Decapping mRNA 1B |
| Gene Type | Protein coding |
| Chromosomal Location | 12p13.33 |
| NCBI Gene ID | 196513 ncbi.nlm.nih.gov/gene/196513 |
| Ensembl ID | ENSG00000111224 |
| UniProt ID | Q8IZD4 |
| OMIM ID | 609843 |
| HGNC ID | 28615 |
| Aliases | DCP1, DCP1B, FLJ11273 |
Description
DCP1B (Decapping mRNA 1B) encodes a component of the mRNA decapping complex, which removes the 5' cap from mRNAs to initiate their degradation. This process is critical for post-transcriptional regulation of gene expression, influencing mRNA stability and turnover. DCP1B interacts with DCP2 and other decapping factors to facilitate mRNA decay, and its dysregulation has been implicated in various cancers and developmental disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Altered mRNA decay affects oncogene and tumor suppressor expression | COSMIC database reports somatic mutations in multiple cancer types |
| Developmental disorders | Potential role in mRNA regulation during development | Inferred from gene function and expression in embryonic tissues |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lymph node | 8.2 | Low |
| Brain | 6.1 | Low |
| Liver | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.0 | Moderate expression |
| HeLa | 7.5 | Low expression |
| K562 | 5.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Unknown functional impact |
| c.250G>A (p.Gly84Ser) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • mRNA decapping | • cytoplasmic processing body |
| • RNA binding | • mRNA catabolic process |
Pathways
• mRNA decay pathway
• RNA degradation
Protein Summary
DCP1B is a 617-amino acid protein that localizes to cytoplasmic processing bodies (P-bodies) and is essential for efficient mRNA decapping. It contains a conserved DCP1 domain that mediates interaction with DCP2 and other decapping cofactors. The protein is widely expressed, with highest levels in testis and lymphoid tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DCP1B Knockout HEK293 Cell Line | EDJ-KQ11562 | Human | 196513 | Details Get a Quote |
| DCP1B Knockout HCT 116 Cell Line | EDJ-KQ38568 | Human | 196513 | Details Get a Quote |
| DCP1B Knockout A-549 Cell Line | EDJ-KQ39895 | Human | 196513 | Details Get a Quote |
| DCP1B Knockout HeLa Cell Line | EDJ-KQ39897 | Human | 196513 | Details Get a Quote |
