DCP1A
Decapping mRNA 1A
Gene Information Card
| Symbol | DCP1A |
|---|---|
| Full Name | Decapping mRNA 1A |
| Gene Type | Protein coding |
| Chromosomal Location | 3p21.1 |
| NCBI Gene ID | 55802 ncbi.nlm.nih.gov/gene/55802 |
| Ensembl ID | ENSG00000163874 |
| UniProt ID | Q9NPI6 |
| OMIM ID | 609841 |
| HGNC ID | 28934 |
| Aliases | DCP1, HSA275986, SMIF, DCP1a |
Description
DCP1A (Decapping mRNA 1A) encodes a core component of the mRNA decapping complex, which removes the 5' cap from mRNAs to initiate their degradation. This process is critical for post-transcriptional regulation of gene expression, mRNA turnover, and nonsense-mediated decay. DCP1A interacts with DCP2 and other decapping factors to facilitate cap hydrolysis. The gene is located on chromosome 3p21.1 and is widely expressed.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered mRNA decapping may affect oncogene/tumor suppressor mRNA stability | COSMIC; literature |
| Neurodevelopmental disorders | Potential role in mRNA regulation in neurons | OMIM; limited evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Lymph node | 12.8 | Medium |
| Brain | 10.5 | Medium |
| Liver | 9.1 | Low |
| Heart | 8.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 14.5 | High expression |
| HeLa | 12.0 | Moderate expression |
| K562 | 10.3 | Moderate expression |
| A549 | 9.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Unknown functional impact |
| c.457G>A (p.Glu153Lys) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; potential reduction in decapping activity
Gain of Function (GOF)
Not reported
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
| • mRNA decapping | • cytoplasmic processing body |
| • RNA binding | • hydrolase activity |
| • nuclear speck |
Pathways
• mRNA surveillance pathway
• RNA degradation
• Nonsense-mediated decay
Protein Summary
DCP1A is a 582-amino acid protein that functions as a scaffold and activator of the mRNA decapping complex. It contains a conserved DCP1 domain and localizes to processing bodies (P-bodies). It interacts with DCP2, EDC3, and other decapping factors to promote cap hydrolysis and mRNA turnover.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DCP1A Knockout HEK293 Cell Line | EDJ-KQ2378 | Human | 55802 | Details Get a Quote |
| DCP1A Knockout A-549 Cell Line | EDJ-KQ21523 | Human | 55802 | Details Get a Quote |
| DCP1A Knockout HCT 116 Cell Line | EDJ-KQ22846 | Human | 55802 | Details Get a Quote |
| DCP1A Knockout HeLa Cell Line | EDJ-KQ22847 | Human | 55802 | Details Get a Quote |
| DCP1A Knockout Huh-7 Cell Line | EDJ-KZ179 | Human | 55802 | Details Get a Quote |
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