DCANP1 (Dendritic Cell-Associated Nuclear Protein 1)
A nuclear protein implicated in dendritic cell function and potential roles in immune regulation and cancer.
Gene Information Card
| Symbol | DCANP1 |
|---|---|
| Full Name | Dendritic Cell-Associated Nuclear Protein 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 5q31.3 |
| NCBI Gene ID | 284756 ncbi.nlm.nih.gov/gene/284756 |
| Ensembl ID | ENSG00000164362 |
| UniProt ID | Q8N8J0 |
| OMIM ID | Not available |
| HGNC ID | HGNC:28759 |
| Aliases | C5orf25, DCANP1 |
Description
DCANP1 (Dendritic Cell-Associated Nuclear Protein 1) is a protein-coding gene located on chromosome 5q31.3. It encodes a nuclear protein that is predominantly expressed in dendritic cells, suggesting a role in immune responses. The protein contains a conserved domain of unknown function (DUF4534) and may be involved in transcriptional regulation or chromatin organization. Limited functional studies indicate potential involvement in dendritic cell maturation and antigen presentation. Recent studies have also implicated DCANP1 in certain cancers, where its expression may correlate with prognosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered expression; potential oncogenic or tumor-suppressive role depending on context | Expression data from TCGA and literature (e.g., breast, lung, colorectal) show differential expression; functional studies are limited. |
| Immune-related disorders | Potential role in dendritic cell function; dysregulation may affect immune responses | Inferred from expression in immune cells; no direct clinical evidence yet. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | Not available | Expected high expression in immune tissues, but data not available in GTEx. |
| Lymph node | Not available | Expected high expression in immune tissues, but data not available in GTEx. |
| Bone marrow | Not available | Expected expression in hematopoietic cells, but data not available in GTEx. |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Dendritic cells (primary) | Not available | High expression reported in literature; specific nTPM not available. |
| Monocytes | Not available | Expression detected; nTPM not available. |
| Macrophages | Not available | Expression detected; nTPM not available. |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1Val) | Missense | Not reported | Potential loss of start codon; effect unknown. |
| c.100C>T (p.Arg34Trp) | Missense | Not reported | Unknown effect; may affect protein function. |
| c.250G>A (p.Ala84Thr) | Missense | Not reported | Unknown effect; may affect protein stability. |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported. Predicted loss-of-function variants (e.g., start codon loss) may lead to reduced protein expression, but functional validation is lacking.
Gain of Function (GOF)
No evidence for gain-of-function mutations. Overexpression in some cancers may suggest oncogenic potential, but no specific activating mutations identified.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • nucleus | • protein binding |
| • immune response | • dendritic cell differentiation |
Pathways
• Immune system (dendritic cell maturation)
• Cancer pathways (potential)
Protein Summary
The DCANP1 protein is a nuclear protein of 289 amino acids (UniProt Q8N8J0). It contains a DUF4534 domain of unknown function. Its expression is enriched in dendritic cells, suggesting a role in antigen presentation and immune regulation. The protein may interact with chromatin or transcription factors, but detailed molecular mechanisms remain to be elucidated. In cancer, DCANP1 expression has been reported to be dysregulated, with potential prognostic significance in certain tumor types.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DCANP1 Knockout HEK293 Cell Line | EDJ-KQ9834 | Human | 140947 | Details Get a Quote |
| DCANP1 Knockout HeLa Cell Line | EDJ-KQ58475 | Human | 140947 | Details Get a Quote |
| DCANP1 Knockout A-549 Cell Line | EDJ-KQ66961 | Human | 140947 | Details Get a Quote |
| DCANP1 Knockout HCT 116 Cell Line | EDJ-KQ75362 | Human | 140947 | Details Get a Quote |
