DCAKD (Dephospho-CoA Kinase Domain Containing)
Gene encoding a putative dephospho-CoA kinase involved in coenzyme A biosynthesis
Gene Information Card
| Symbol | DCAKD |
|---|---|
| Full Name | Dephospho-CoA Kinase Domain Containing |
| Gene Type | Protein coding |
| Chromosomal Location | 17q21.2 |
| NCBI Gene ID | 55235 ncbi.nlm.nih.gov/gene/55235 |
| Ensembl ID | ENSG00000172977 |
| UniProt ID | Q8N5K1 |
| OMIM ID | 617405 |
| HGNC ID | 25523 |
| Aliases | FLJ10330, MGC138499 |
Description
DCAKD (Dephospho-CoA Kinase Domain Containing) is a protein-coding gene located on chromosome 17q21.2. The encoded protein contains a dephospho-CoA kinase domain, which is predicted to catalyze the ATP-dependent phosphorylation of dephospho-CoA to form coenzyme A (CoA), a critical cofactor in numerous metabolic pathways. The gene is broadly expressed in human tissues, with highest levels in the liver and kidney. DCAKD is also known as FLJ10330 and MGC138499.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease association reported in ClinVar or OMIM | Not established | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 10.2 | Medium |
| Heart | 7.8 | Low |
| Brain | 5.3 | Low |
| Lung | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 14.0 | Hepatocellular carcinoma cell line |
| HEK 293 | 9.5 | Embryonic kidney cell line |
| K-562 | 6.2 | Leukemia cell line |
| HeLa | 5.0 | Cervical carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • ATP binding (GO:0005524) | • kinase activity (GO:0016301) |
| • phosphorylation (GO:0016310) | • coenzyme A biosynthetic process (GO:0015937) |
| • cytoplasm (GO:0005737) |
Pathways
• Pantothenate and CoA biosynthesis (KEGG: hsa00770)
• Metabolic pathways (KEGG: hsa01100)
Protein Summary
The DCAKD protein (UniProt Q8N5K1) is a 364-amino acid polypeptide with a predicted molecular mass of approximately 41 kDa. It contains a conserved dephospho-CoA kinase domain (Pfam PF01121) that is structurally related to the CoaE family of enzymes. The protein is predicted to localize to the cytoplasm and is involved in the final step of coenzyme A biosynthesis, converting dephospho-CoA to CoA using ATP. No crystal structure is currently available, and functional validation remains limited.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DCAKD Knockout HEK293 Cell Line | EDJ-KQ12326 | Human | 79877 | Details Get a Quote |
| DCAKD Knockout A-549 Cell Line | EDJ-KQ42397 | Human | 79877 | Details Get a Quote |
| DCAKD Knockout HCT 116 Cell Line | EDJ-KQ42399 | Human | 79877 | Details Get a Quote |
| DCAKD Knockout HeLa Cell Line | EDJ-KQ42400 | Human | 79877 | Details Get a Quote |
