DCAF10
DDB1 and CUL4 Associated Factor 10
Gene Information Card
| Symbol | DCAF10 |
|---|---|
| Full Name | DDB1 and CUL4 Associated Factor 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 9p13.3 |
| NCBI Gene ID | 79269 ncbi.nlm.nih.gov/gene/79269 |
| Ensembl ID | ENSG00000107175 |
| UniProt ID | Q5T1R4 |
| OMIM ID | 617738 |
| HGNC ID | 20260 |
| Aliases | WDR32, FLJ11273 |
Description
DCAF10 (DDB1 and CUL4 Associated Factor 10) encodes a WD40-repeat-containing protein that functions as a substrate receptor for the CUL4-DDB1 E3 ubiquitin ligase complex. It is involved in ubiquitination and proteasomal degradation of target proteins, regulating cellular processes such as cell cycle and DNA repair.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Somatic mutations may alter substrate recognition in CRL4 complexes, affecting tumor suppressor degradation | COSMIC |
| Neurodevelopmental disorder | Potential role via ubiquitin pathway dysregulation; limited evidence | ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Lung | 6.1 | Low |
| Liver | 5.3 | Low |
| Kidney | 4.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.3 | Moderate expression |
| HeLa | 8.7 | Moderate expression |
| K562 | 6.4 | Low expression |
| A549 | 5.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339Trp) | Missense | <0.01% | Unknown functional impact |
| c.1246G>A (p.Gly416Ser) | Missense | <0.01% | Reported in COSMIC; potential loss of function |
Mutation functional classification
Loss of Function (LOF)
Missense mutations in WD40 repeats may impair substrate binding and ubiquitination.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • ubiquitin-protein transferase activity | • protein ubiquitination |
| • WD40-repeat domain binding | • CUL4-RING E3 ubiquitin ligase complex |
Pathways
• CUL4-DDB1 ubiquitin ligase pathway
• Ubiquitin mediated proteolysis
Protein Summary
DCAF10 is a 546-amino-acid protein containing multiple WD40 repeats that form a beta-propeller structure. It acts as a substrate receptor for the CRL4 E3 ubiquitin ligase, recruiting specific proteins for ubiquitination and subsequent degradation by the proteasome.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DCAF10 Knockout HEK293 Cell Line | EDJ-KQ13100 | Human | 79269 | Details Get a Quote |
| DCAF10 Knockout A-549 Cell Line | EDJ-KQ41163 | Human | 79269 | Details Get a Quote |
| DCAF10 Knockout HCT 116 Cell Line | EDJ-KQ42392 | Human | 79269 | Details Get a Quote |
| DCAF10 Knockout HeLa Cell Line | EDJ-KQ42393 | Human | 79269 | Details Get a Quote |
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