DBP Gene: D-Box Binding PAR BZIP Transcription Factor
Comprehensive gene card for DBP, a circadian clock-regulated transcription factor involved in metabolic and hepatic functions.
Gene Information Card
| Symbol | DBP |
|---|---|
| Full Name | D-box binding PAR bZIP transcription factor |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.33 |
| NCBI Gene ID | 1628 ncbi.nlm.nih.gov/gene/1628 |
| Ensembl ID | ENSG00000105516 |
| UniProt ID | Q10586 |
| OMIM ID | 124097 |
| HGNC ID | 2697 |
| Aliases | DABP, DBP1, PARP1 |
Description
DBP (D-box binding PAR bZIP transcription factor) is a member of the proline and acidic amino acid-rich (PAR) basic leucine zipper (bZIP) transcription factor family. It binds to D-box elements in gene promoters and is regulated by the circadian clock, playing a key role in the rhythmic expression of genes involved in metabolism, particularly in the liver. DBP is also implicated in the regulation of cell cycle and stress responses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | DBP overexpression may contribute to tumor progression by altering circadian gene expression and metabolic pathways. | PMID: 25636800 |
| Circadian rhythm sleep disorder | Variants in DBP can disrupt clock-controlled gene expression, potentially leading to sleep phase abnormalities. | PMID: 28481359 |
| Metabolic syndrome | DBP dysregulation affects hepatic lipid and glucose metabolism, linking it to obesity and insulin resistance. | PMID: 29127255 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | High |
| Kidney | 8.3 | Medium |
| Heart | 5.1 | Medium |
| Brain | 2.0 | Low |
| Lung | 1.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 10.2 | Hepatocellular carcinoma cell line; high DBP expression |
| HEK293 | 4.5 | Embryonic kidney cells; moderate expression |
| A549 | 2.1 | Lung carcinoma cells; low expression |
| K562 | 1.0 | Leukemia cells; very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.502C>T (p.Arg168Trp) | Missense | <0.01% | Altered DNA-binding affinity; potential loss of function |
| c.763G>A (p.Gly255Ser) | Missense | <0.01% | Reduced transcriptional activity; associated with circadian disruption |
| c.1000_1001insA | Frameshift | <0.01% | Premature truncation; loss of function |
Mutation functional classification
Loss of Function (LOF)
Missense and frameshift mutations that reduce or eliminate DNA-binding or transactivation activity.
Gain of Function (GOF)
Not reported in curated databases.
Dominant Negative (DN)
Not reported in curated databases.
View complete mutation data：
Gene Ontology (GO)
| • GO:0000978 (GO:0000978) | • GO:0000981 (GO:0000981) |
| • GO:0003700 (GO:0003700) | • GO:0005515 (GO:0005515) |
| • GO:0005634 (GO:0005634) | • GO:0006351 (GO:0006351) |
| • GO:0006355 (GO:0006355) | • GO:0007623 (GO:0007623) |
| • GO:0045944 (GO:0045944) | • GO:0070887 (GO:0070887) |
Pathways
• Circadian rhythm (KEGG: hsa04710)
• Transcriptional regulation by the bZIP transcription factors (Reactome: R-HSA-212436)
Protein Summary
The DBP protein (UniProt Q10586) is a 420-amino acid transcription factor containing a bZIP domain and a PAR domain. It forms homodimers or heterodimers with other PAR bZIP factors (e.g., TEF, HLF) and binds to D-box sequences (5'-RTTAYGTAAY-3') in target gene promoters. DBP exhibits circadian oscillation in the liver, peaking during the day, and regulates genes involved in detoxification, gluconeogenesis, and lipid metabolism. Post-translational modifications include phosphorylation, which modulates its stability and activity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DBP Knockout HEK293 Cell Line | EDJ-KQ2739 | Human | 1628 | Details Get a Quote |
| CCNDBP1 Knockout HEK293 Cell Line | EDJ-KQ8084 | Human | 23582 | Details Get a Quote |
| TARDBP Knockout HEK293 Cell Line | EDJ-KQ17905 | Human | 23435 | Details Get a Quote |
| CCNDBP1 Knockout A-549 Cell Line | EDJ-KQ33929 | Human | 23582 | Details Get a Quote |
| CCNDBP1 Knockout HCT 116 Cell Line | EDJ-KQ33930 | Human | 23582 | Details Get a Quote |
| CCNDBP1 Knockout HeLa Cell Line | EDJ-KQ33931 | Human | 23582 | Details Get a Quote |
| DBP Knockout A-549 Cell Line | EDJ-KQ23612 | Human | 1628 | Details Get a Quote |
| DBP Knockout HCT 116 Cell Line | EDJ-KQ23613 | Human | 1628 | Details Get a Quote |
| DBP Knockout HeLa Cell Line | EDJ-KQ23614 | Human | 1628 | Details Get a Quote |
| TARDBP Knockout HeLa Cell Line | EDJ-KQ55738 | Human | 23435 | Details Get a Quote |
| TARDBP Knockout A-549 Cell Line | EDJ-KQ64236 | Human | 23435 | Details Get a Quote |
| TARDBP Knockout HCT 116 Cell Line | EDJ-KQ72681 | Human | 23435 | Details Get a Quote |
| TARDBP Knockout HAP1 Cell Line | EDJ-KQ78120 | Human | 23435 | Details Get a Quote |
Displaying Records 1 To 13 Of 13 Records
