DBF4B
DBF4 zinc finger B
Gene Information Card
| Symbol | DBF4B |
|---|---|
| Full Name | DBF4 zinc finger B |
| Gene Type | protein-coding |
| Chromosomal Location | 17q21.31 |
| NCBI Gene ID | 80174 ncbi.nlm.nih.gov/gene/80174 |
| Ensembl ID | ENSG00000141384 |
| UniProt ID | Q8NFT6 |
| OMIM ID | 611661 |
| HGNC ID | 17356 |
| Aliases | ASK1, DRF1, ZDBF1B |
Description
DBF4B encodes a regulatory subunit of the CDC7 kinase complex, essential for initiation of DNA replication and cell cycle progression. It interacts with CDC7 to activate the kinase activity required for origin firing during S phase.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Overexpression may drive proliferation via CDC7 activation | COSMIC; PMID: 21502544 |
| Breast cancer | Amplification of DBF4B locus observed | COSMIC; PMID: 22955915 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Bone marrow | 8.3 | Medium |
| Lymph node | 6.1 | Low |
| Brain | 2.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.2 | High expression |
| HeLa | 10.8 | Medium expression |
| MCF7 | 7.5 | Medium expression |
| K562 | 5.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339Trp) | Missense | <0.1% | Unknown functional impact |
| c.1246G>A (p.Gly416Ser) | Missense | <0.1% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
Amplification and overexpression may confer gain-of-function in cancer.
Dominant Negative (DN)
No dominant-negative variants described.
View complete mutation data：
Gene Ontology (GO)
| • protein kinase binding | • zinc ion binding |
| • cell cycle | • DNA replication initiation |
| • CDC7-DBF4 complex |
Pathways
• Cell Cycle (Reactome R-HSA-1640170)
• Activation of CDC7 (Reactome R-HSA-68962)
Protein Summary
DBF4B is a 674-amino acid protein containing a zinc finger domain. It forms a complex with CDC7 kinase, regulating its activity and localization. The protein is essential for G1/S transition and DNA replication licensing.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DBF4B Knockout HEK293 Cell Line | EDJ-KQ9470 | Human | 80174 | Details Get a Quote |
| DBF4B Knockout HCT 116 Cell Line | EDJ-KQ34932 | Human | 80174 | Details Get a Quote |
| DBF4B Knockout A-549 Cell Line | EDJ-KQ36177 | Human | 80174 | Details Get a Quote |
| DBF4B Knockout HeLa Cell Line | EDJ-KQ36178 | Human | 80174 | Details Get a Quote |
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