DAPL1
Death Associated Protein Like 1
Gene Information Card
| Symbol | DAPL1 |
|---|---|
| Full Name | Death Associated Protein Like 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 2q24.1 |
| NCBI Gene ID | 92196 ncbi.nlm.nih.gov/gene/92196 |
| Ensembl ID | ENSG00000163026 |
| UniProt ID | Q9Y6J0 |
| OMIM ID | 610451 |
| HGNC ID | 25416 |
| Aliases | DAPL1, DAP-like 1, DAPL1 protein |
Description
DAPL1 (Death Associated Protein Like 1) is a protein-coding gene located on chromosome 2q24.1. It encodes a protein that is structurally similar to death-associated protein (DAP) and is involved in apoptosis and cell cycle regulation. DAPL1 is expressed in various tissues and has been implicated in cancer and other diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | DAPL1 may act as a tumor suppressor; altered expression linked to apoptosis dysregulation | Limited; expression changes observed in some cancer types (e.g., breast, lung) via NCBI Gene and COSMIC |
| Retinal degeneration | Potential role in photoreceptor survival; DAPL1 expression in retina | Preliminary; based on expression data and homology to DAP |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 10.2 | Medium |
| Retina | 8.5 | Medium |
| Brain | 5.1 | Low |
| Lung | 3.8 | Low |
| Breast | 2.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 4.5 | Low expression |
| MCF7 | 2.1 | Low expression |
| A549 | 3.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T | Missense | <0.1% | Unknown; rare variant reported in COSMIC |
| c.456G>A | Synonymous | <0.1% | No functional effect predicted |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; potential loss of apoptotic function if missense mutations disrupt protein structure.
Gain of Function (GOF)
No evidence for gain-of-function mutations.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • apoptotic process | • regulation of cell cycle |
| • protein binding |
Pathways
• Apoptosis signaling pathway
Protein Summary
The DAPL1 protein is a 150-amino acid polypeptide that shares homology with death-associated protein (DAP). It is localized to the cytoplasm and may regulate apoptosis through interactions with other death-associated proteins. Its exact molecular function remains under investigation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DAPL1 Knockout HEK293 Cell Line | EDJ-KQ10849 | Human | 92196 | Details Get a Quote |
| DAPL1 Knockout HeLa Cell Line | EDJ-KQ38514 | Human | 92196 | Details Get a Quote |
| DAPL1 Knockout A-549 Cell Line | EDJ-KQ66326 | Human | 92196 | Details Get a Quote |
| DAPL1 Knockout HCT 116 Cell Line | EDJ-KQ74750 | Human | 92196 | Details Get a Quote |
