DAP (Death-Associated Protein) Gene
Key regulator of apoptosis and autophagy
Gene Information Card
| Symbol | DAP |
|---|---|
| Full Name | Death Associated Protein |
| Gene Type | protein-coding |
| Chromosomal Location | 5p15.2 |
| NCBI Gene ID | 1611 ncbi.nlm.nih.gov/gene/1611 |
| Ensembl ID | ENSG00000113558 |
| UniProt ID | P51397 |
| OMIM ID | 600954 |
| HGNC ID | 2672 |
| Aliases | DAP-1, DAP1 |
Description
The DAP gene encodes the death-associated protein, a pro-apoptotic serine/threonine kinase involved in interferon-gamma-induced cell death, autophagy, and tumor suppression. It functions as a positive mediator of programmed cell death and is implicated in various cancers and neurodegenerative disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | Loss of DAP expression reduces apoptosis, promoting tumorigenesis | PMID: 10655551 |
| Lung Cancer | DAP promoter methylation silences gene expression, linked to poor prognosis | PMID: 15126332 |
| Alzheimer's Disease | DAP mediates neuronal cell death via autophagy dysregulation | PMID: 20080799 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.3 | Medium |
| Breast | 8.7 | Low |
| Brain | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.2 | Cervical cancer cell line |
| A549 | 10.1 | Lung cancer cell line |
| MCF7 | 6.8 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown functional effect |
| c.235C>T | Nonsense | <0.01% | Premature truncation, loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations leading to truncated protein, reducing pro-apoptotic activity.
Gain of Function (GOF)
Not reported in DAP.
Dominant Negative (DN)
Not reported in DAP.
View complete mutation data：
Gene Ontology (GO)
| • apoptotic process | • protein serine/threonine kinase activity |
| • autophagy | • positive regulation of cell death |
| • cytoplasm |
Pathways
• Apoptosis
• Autophagy
• p53 signaling pathway
Protein Summary
Death-associated protein (DAP) is a 102-amino acid protein with a serine/threonine kinase domain. It localizes to the cytoplasm and is activated by interferon-gamma, leading to phosphorylation of downstream targets that promote apoptosis and autophagy. DAP is frequently silenced by promoter methylation in cancers, acting as a tumor suppressor.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| DAPK1 Knockout HEK293 Cell Line | EDJ-KQ3701 | Human | 1612 | Details Get a Quote |
| DAP Knockout HEK293 Cell Line | EDJ-KQ4420 | Human | 1611 | Details Get a Quote |
| DAPK3 Knockout HEK293 Cell Line | EDJ-KQ4421 | Human | 1613 | Details Get a Quote |
| DAPK2 Knockout HEK293 Cell Line | EDJ-KQ8090 | Human | 23604 | Details Get a Quote |
| DAPP1 Knockout HEK293 Cell Line | EDJ-KQ8667 | Human | 27071 | Details Get a Quote |
| DAPL1 Knockout HEK293 Cell Line | EDJ-KQ10849 | Human | 92196 | Details Get a Quote |
| DAP Knockout A-549 Cell Line | EDJ-KQ26946 | Human | 1611 | Details Get a Quote |
| DAP Knockout HCT 116 Cell Line | EDJ-KQ26947 | Human | 1611 | Details Get a Quote |
| DAP Knockout HeLa Cell Line | EDJ-KQ26948 | Human | 1611 | Details Get a Quote |
| DAPK3 Knockout A-549 Cell Line | EDJ-KQ26949 | Human | 1613 | Details Get a Quote |
| DAPK3 Knockout HCT 116 Cell Line | EDJ-KQ26950 | Human | 1613 | Details Get a Quote |
| DAPK2 Knockout A-549 Cell Line | EDJ-KQ33940 | Human | 23604 | Details Get a Quote |
| DAPK2 Knockout HCT 116 Cell Line | EDJ-KQ33941 | Human | 23604 | Details Get a Quote |
| DAPK2 Knockout HeLa Cell Line | EDJ-KQ33942 | Human | 23604 | Details Get a Quote |
| DAPK1 Knockout A-549 Cell Line | EDJ-KQ24343 | Human | 1612 | Details Get a Quote |
