CYYR1
Cysteine and Tyrosine Rich 1
Gene Information Card
| Symbol | CYYR1 |
|---|---|
| Full Name | Cysteine and Tyrosine Rich 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 21q21.1 |
| NCBI Gene ID | 116159 ncbi.nlm.nih.gov/gene/116159 |
| Ensembl ID | ENSG00000160209 |
| UniProt ID | Q96J86 |
| OMIM ID | 616563 |
| HGNC ID | 26876 |
| Aliases | C21orf95, DKFZp434D2228 |
Description
CYYR1 (Cysteine and Tyrosine Rich 1) is a protein-coding gene located on chromosome 21q21.1. It encodes a protein characterized by a high content of cysteine and tyrosine residues. The function of CYYR1 is not fully characterized, but it is predicted to be involved in cellular signaling or structural roles. Expression data suggest broad tissue distribution with notable levels in the brain and testis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 5.2 | Low |
| Testis | 4.8 | Low |
| Lung | 3.1 | Low |
| Heart | 2.5 | Low |
| Liver | 1.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 3.0 | Low expression |
| K562 | 2.1 | Low expression |
| HeLa | 1.5 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
Not established
Gain of Function (GOF)
Not established
Dominant Negative (DN)
Not established
View complete mutation data：
Protein Summary
The CYYR1 protein is predicted to be a small, secreted or membrane-associated protein due to its cysteine and tyrosine-rich composition. No enzymatic or structural function has been experimentally validated. It may play a role in cell-cell communication or extracellular matrix interactions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CYYR1 Knockout HEK293 Cell Line | EDJ-KQ7551 | Human | 116159 | Details Get a Quote |
| CYYR1 Knockout HeLa Cell Line | EDJ-KQ57972 | Human | 116159 | Details Get a Quote |
| CYYR1 Knockout A-549 Cell Line | EDJ-KQ66462 | Human | 116159 | Details Get a Quote |
| CYYR1 Knockout HCT 116 Cell Line | EDJ-KQ74883 | Human | 116159 | Details Get a Quote |
