CYSLTR2
Cysteinyl Leukotriene Receptor 2
Gene Information Card
| Symbol | CYSLTR2 |
|---|---|
| Full Name | Cysteinyl Leukotriene Receptor 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 13q14.2 |
| NCBI Gene ID | 57105 ncbi.nlm.nih.gov/gene/57105 |
| Ensembl ID | ENSG00000152219 |
| UniProt ID | Q9NS75 |
| OMIM ID | 605666 |
| HGNC ID | 18274 |
| Aliases | CYSLT2, CYSLT2R, hGPCR21, HG57 |
Description
CYSLTR2 encodes the cysteinyl leukotriene receptor 2, a G protein-coupled receptor that binds cysteinyl leukotrienes (LTC4, LTD4, LTE4). It is involved in inflammatory responses, smooth muscle contraction, and vascular permeability. Activating mutations in CYSLTR2 are associated with uveal melanoma.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Uveal melanoma | Activating mutation (p.Leu129Gln) leads to constitutive Gq/11 signaling | COSMIC, ClinVar |
| Asthma | Receptor mediates bronchoconstriction and airway inflammation | NCBI Gene, OMIM |
| Allergic rhinitis | Leukotriene signaling contributes to nasal inflammation | NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 8.2 | Medium |
| Lung | 6.5 | Medium |
| Small intestine | 5.1 | Low |
| Heart | 3.8 | Low |
| Liver | 1.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 12.3 | Overexpressed in recombinant studies |
| A375 (melanoma) | 9.7 | Endogenous expression |
| HUVEC | 7.1 | Endothelial expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| p.Leu129Gln | Missense | ~4% in uveal melanoma | Gain-of-function, constitutive Gq signaling |
| p.Tyr134Cys | Missense | Rare | Likely gain-of-function |
| p.Arg239His | Missense | Rare | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
Not reported
Gain of Function (GOF)
p.Leu129Gln, p.Tyr134Cys
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • cysteinyl leukotriene receptor activity |
| • signal transduction | • inflammatory response |
| • cell surface receptor signaling pathway |
Pathways
• Leukotriene signaling
• Gq/11-mediated signaling
• Calcium mobilization
Protein Summary
CYSLTR2 is a 346-amino acid G protein-coupled receptor with seven transmembrane domains. It preferentially couples to Gq/11 proteins, leading to phospholipase C activation, calcium release, and PKC signaling. The receptor is a therapeutic target for asthma and allergic diseases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CYSLTR2 Knockout HEK293 Cell Line | EDJ-KQ1582 | Human | 57105 | Details Get a Quote |
| CYSLTR2 Knockout HeLa Cell Line | EDJ-KQ56802 | Human | 57105 | Details Get a Quote |
| CYSLTR2 Knockout A-549 Cell Line | EDJ-KQ65308 | Human | 57105 | Details Get a Quote |
| CYSLTR2 Knockout HCT 116 Cell Line | EDJ-KQ73749 | Human | 57105 | Details Get a Quote |
