CYRIB Gene
CYRIB, a member of the CYRI family involved in cell migration and actin dynamics
Gene Information Card
| Symbol | CYRIB |
|---|---|
| Full Name | CYFIP related Rac1 interactor B |
| Gene Type | protein-coding |
| Chromosomal Location | 5q31.3 |
| NCBI Gene ID | 348013 ncbi.nlm.nih.gov/gene/348013 |
| Ensembl ID | ENSG00000164327 |
| UniProt ID | Q9NUQ9 |
| OMIM ID | 617359 |
| HGNC ID | 26248 |
| Aliases | FAM49B, CGI-48, PRO1855 |
Description
CYRIB (CYFIP related Rac1 interactor B) is a protein-coding gene that encodes a member of the CYRI (CYFIP-related Rac1 interactor) family. The protein is involved in regulating actin dynamics and cell migration by interacting with Rac1 and modulating lamellipodia formation. CYRIB is widely expressed in various tissues and has been implicated in cancer progression and immune cell function.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Altered CYRIB expression may affect cell migration and invasion via Rac1 signaling | COSMIC, PubMed |
| Breast cancer | Upregulation of CYRIB associated with poor prognosis and metastasis | COSMIC, PubMed |
| Inflammatory bowel disease | CYRIB variants linked to immune dysregulation | ClinVar, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 15.2 | Medium |
| Lung | 12.8 | Medium |
| Liver | 8.5 | Low |
| Kidney | 10.1 | Medium |
| Testis | 20.3 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 18.5 | High expression |
| HEK293 | 14.2 | Medium expression |
| MCF7 | 22.1 | High expression |
| A549 | 11.7 | Medium expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.287A>G (p.Asn96Ser) | Missense | <0.01% | Unknown functional impact |
| c.512C>T (p.Pro171Leu) | Missense | <0.01% | Likely benign |
| c.739G>A (p.Gly247Arg) | Missense | <0.01% | Uncertain significance |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in CYRIB.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in CYRIB.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported in CYRIB.
View complete mutation data：
Gene Ontology (GO)
| • actin binding (GO:0003779) | • actin cytoskeleton organization (GO:0030036) |
| • positive regulation of GTPase activity (GO:0043547) | • cell migration (GO:0016477) |
| • cytosol (GO:0005829) |
Pathways
• Rac1 signaling pathway
• Regulation of actin cytoskeleton
Protein Summary
The CYRIB protein (UniProt Q9NUQ9) is a 290-amino acid protein that localizes to the cytosol and interacts with Rac1. It functions as a negative regulator of Rac1 activity, thereby controlling lamellipodia formation and cell migration. CYRIB is evolutionarily conserved and expressed in multiple tissues, with highest levels in testis and certain cancer cell lines.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CYRIB Knockout HEK293 Cell Line | EDJ-KQ1922 | Human | 51571 | Details Get a Quote |
| CYRIB Knockout A-549 Cell Line | EDJ-KQ20543 | Human | 51571 | Details Get a Quote |
| CYRIB Knockout HCT 116 Cell Line | EDJ-KQ21841 | Human | 51571 | Details Get a Quote |
| CYRIB Knockout HeLa Cell Line | EDJ-KQ21842 | Human | 51571 | Details Get a Quote |
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