CYREN (Cell Cycle Regulator of NHEJ)
A key inhibitor of classical non-homologous end joining during the S and G2 phases of the cell cycle.
Gene Information Card
| Symbol | CYREN |
|---|---|
| Full Name | Cell cycle regulator of NHEJ |
| Gene Type | Protein coding |
| Chromosomal Location | 19q13.11 |
| NCBI Gene ID | 123688 ncbi.nlm.nih.gov/gene/123688 |
| Ensembl ID | ENSG00000105639 |
| UniProt ID | Q9H0U4 |
| OMIM ID | 617749 |
| HGNC ID | 26170 |
| Aliases | C19orf61, CGI-128, NHEJ regulator |
Description
CYREN (cell cycle regulator of NHEJ) encodes a protein that inhibits classical non-homologous end joining (c-NHEJ) during the S and G2 phases of the cell cycle. By binding to the Ku70/80 complex, CYREN promotes the use of alternative end-joining pathways, thereby influencing genomic stability and DNA repair fidelity.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Dysregulation of CYREN may alter DNA repair pathway choice, leading to genomic instability and tumorigenesis. | COSMIC; ClinVar |
| Immunodeficiency | Potential impact on V(D)J recombination due to altered NHEJ regulation. | OMIM #617749 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lymph node | 8.2 | Low |
| Bone marrow | 6.7 | Low |
| Brain | 3.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 10.1 | Cervical cancer cell line |
| K562 | 7.8 | Leukemia cell line |
| HEK293 | 5.4 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.287G>A (p.Arg96His) | Missense | <0.01% | Unknown functional impact |
| c.412C>T (p.Arg138*) | Nonsense | <0.01% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., p.Arg138*) are predicted to cause loss of CYREN protein function, potentially impairing cell cycle-dependent NHEJ regulation.
Gain of Function (GOF)
No gain-of-function mutations have been reported in CYREN.
Dominant Negative (DN)
No dominant-negative mutations have been described for CYREN.
View complete mutation data：
Gene Ontology (GO)
| • double-strand break repair via nonhomologous end joining (GO:0006303) | • nucleus (GO:0005634) |
| • identical protein binding (GO:0042802) | • protein binding (GO:0005515) |
Pathways
• Non-homologous end joining (NHEJ) pathway
• DNA double-strand break repair
Protein Summary
The CYREN protein (UniProt Q9H0U4) is a 299-amino-acid nuclear protein that contains a conserved N-terminal domain mediating interaction with the Ku70/80 heterodimer. It acts as a cell cycle-dependent switch, inhibiting c-NHEJ in S/G2 to favor alternative end-joining, thereby contributing to genomic stability.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CYREN Knockout HEK293 Cell Line | EDJ-KQ13086 | Human | 78996 | Details Get a Quote |
| CYREN Knockout A-549 Cell Line | EDJ-KQ42368 | Human | 78996 | Details Get a Quote |
| CYREN Knockout HCT 116 Cell Line | EDJ-KQ42369 | Human | 78996 | Details Get a Quote |
| CYREN Knockout HeLa Cell Line | EDJ-KQ42370 | Human | 78996 | Details Get a Quote |
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