CYP4F11
Cytochrome P450 Family 4 Subfamily F Member 11
Gene Information Card
| Symbol | CYP4F11 |
|---|---|
| Full Name | Cytochrome P450 Family 4 Subfamily F Member 11 |
| Gene Type | protein-coding |
| Chromosomal Location | 19p13.12 |
| NCBI Gene ID | 57834 ncbi.nlm.nih.gov/gene/57834 |
| Ensembl ID | ENSG00000171954 |
| UniProt ID | Q9HBI6 |
| OMIM ID | 611511 |
| HGNC ID | 26463 |
| Aliases | CYP4F12, CYP4F13, CYP4F14 |
Description
CYP4F11 is a member of the cytochrome P450 superfamily of enzymes, which are involved in the metabolism of various endogenous and exogenous compounds. This gene encodes a protein that catalyzes the omega-hydroxylation of long-chain fatty acids and leukotrienes, playing a role in lipid metabolism and inflammatory responses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hypertension | Altered metabolism of arachidonic acid derivatives affecting vascular tone | ClinVar |
| Cardiovascular disease | Dysregulation of eicosanoid metabolism | NCBI Gene |
| Inflammatory disorders | Modulation of leukotriene B4 levels | UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 8.3 | Medium |
| Lung | 6.1 | Low |
| Small intestine | 4.9 | Low |
| Heart | 2.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.2 | Hepatocyte-derived |
| HEK293 | 7.8 | Embryonic kidney |
| A549 | 5.4 | Lung carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs2072800 | SNP | 0.15 | Missense variant, potential altered enzyme activity |
| rs1065852 | SNP | 0.08 | Synonymous, no known functional effect |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants may reduce catalytic activity toward leukotriene B4.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • omega-hydroxylase activity | • arachidonic acid omega-hydroxylase activity |
| • heme binding | • iron ion binding |
| • oxidoreductase activity |
Pathways
• Arachidonic acid metabolism
• Leukotriene metabolism
• Fatty acid omega-hydroxylation
Protein Summary
The CYP4F11 protein is a microsomal cytochrome P450 monooxygenase that catalyzes the omega-hydroxylation of long-chain fatty acids and leukotrienes, particularly leukotriene B4, thereby modulating inflammatory signaling. It is expressed primarily in liver and kidney.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CYP4F11 Knockout HEK293 Cell Line | EDJ-KQ13075 | Human | 57834 | Details Get a Quote |
| CYP4F11 Knockout A-549 Cell Line | EDJ-KQ42351 | Human | 57834 | Details Get a Quote |
| CYP4F11 Knockout HCT 116 Cell Line | EDJ-KQ42352 | Human | 57834 | Details Get a Quote |
| CYP4F11 Knockout HeLa Cell Line | EDJ-KQ42353 | Human | 57834 | Details Get a Quote |
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