CYP2J2
Cytochrome P450 Family 2 Subfamily J Member 2
Gene Information Card
| Symbol | CYP2J2 |
|---|---|
| Full Name | Cytochrome P450 Family 2 Subfamily J Member 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 1p31.3-p31.2 |
| NCBI Gene ID | 1573 ncbi.nlm.nih.gov/gene/1573 |
| Ensembl ID | ENSG00000134716 |
| UniProt ID | P51589 |
| OMIM ID | 601258 |
| HGNC ID | 2634 |
| Aliases | CPJ2, CYPIIJ2 |
Description
CYP2J2 encodes a member of the cytochrome P450 superfamily of enzymes, which are heme-thiolate monooxygenases involved in the metabolism of various endogenous and exogenous compounds. CYP2J2 is primarily expressed in the heart and vascular endothelium and is a major enzyme for the epoxidation of arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs), which have vasodilatory, anti-inflammatory, and cardioprotective effects. The gene is also implicated in drug metabolism and cancer biology.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cardiovascular disease | CYP2J2-derived EETs regulate vascular tone and inflammation; reduced activity may contribute to hypertension and atherosclerosis. | PMID: 15689448, ClinVar |
| Cancer (various types) | CYP2J2 is overexpressed in several cancers and promotes tumor growth and angiogenesis via EET signaling. | PMID: 21750195, COSMIC |
| Coronary artery disease | Polymorphisms in CYP2J2 are associated with altered EET levels and risk of CAD. | PMID: 17261634, OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 27.8 | High |
| Liver | 5.2 | Low |
| Kidney | 4.1 | Low |
| Lung | 3.9 | Low |
| Vascular endothelium | N/A | High (protein level) |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HUVEC | N/A | High expression of CYP2J2 mRNA and protein |
| HepG2 | N/A | Moderate expression |
| A549 | N/A | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs890293 (CYP2J2*7) | Promoter variant | ~5-10% in some populations | Reduced promoter activity and lower EET levels, associated with increased cardiovascular risk |
| rs11572325 | Missense (Ile192Val) | Rare | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
rs890293 (CYP2J2*7) reduces transcriptional activity, leading to decreased CYP2J2 expression and lower EET production.
Gain of Function (GOF)
No well-characterized gain-of-function mutations reported.
Dominant Negative (DN)
Not described for CYP2J2.
View complete mutation data：
Gene Ontology (GO)
| • arachidonic acid epoxygenase activity | • heme binding |
| • iron ion binding | • oxidoreductase activity |
| • acting on paired donors | • with incorporation or reduction of molecular oxygen |
| • monooxygenase activity |
Pathways
• Arachidonic acid metabolism
• Epoxidation of arachidonic acid to EETs
• Biological oxidations
Protein Summary
CYP2J2 is a 502-amino acid microsomal cytochrome P450 monooxygenase localized to the endoplasmic reticulum. It catalyzes the NADPH-dependent epoxidation of arachidonic acid to four regioisomeric EETs (5,6-, 8,9-, 11,12-, and 14,15-EET). These EETs act as autocrine and paracrine signaling molecules that promote vasodilation, inhibit platelet aggregation, and reduce inflammation. CYP2J2 also metabolizes several drugs, including ebastine and terfenadine. The protein is highly expressed in the heart and vascular endothelium, with lower levels in liver, kidney, and lung.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CYP2J2 Knockout HEK293 Cell Line | EDJ-KQ4405 | Human | 1573 | Details Get a Quote |
| CYP2J2 Knockout HCT 116 Cell Line | EDJ-KQ26930 | Human | 1573 | Details Get a Quote |
| CYP2J2 Knockout HeLa Cell Line | EDJ-KQ53052 | Human | 1573 | Details Get a Quote |
| CYP2J2 Knockout A-549 Cell Line | EDJ-KQ61517 | Human | 1573 | Details Get a Quote |
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