CYP2F1
Cytochrome P450 Family 2 Subfamily F Member 1
Gene Information Card
| Symbol | CYP2F1 |
|---|---|
| Full Name | Cytochrome P450 Family 2 Subfamily F Member 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 19q13.2 |
| NCBI Gene ID | 1572 ncbi.nlm.nih.gov/gene/1572 |
| Ensembl ID | ENSG00000104814 |
| UniProt ID | P24903 |
| OMIM ID | 124070 |
| HGNC ID | 2629 |
| Aliases | CYP2F, CYPIIF1 |
Description
CYP2F1 encodes a member of the cytochrome P450 superfamily of enzymes, which are heme-thiolate monooxygenases involved in the metabolism of xenobiotics and endogenous compounds. This protein is primarily expressed in the lung and metabolizes several pulmonary toxicants, including naphthalene and styrene. CYP2F1 is also involved in the bioactivation of certain procarcinogens.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung cancer | Bioactivation of procarcinogens leading to DNA damage | PMID: 10534357 |
| Chronic obstructive pulmonary disease (COPD) | Altered xenobiotic metabolism in lung epithelium | PMID: 22968130 |
| Chemical-induced pneumotoxicity | Metabolic activation of naphthalene and styrene | PMID: 10640619 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.3 | Medium |
| Liver | 0.8 | Not detected |
| Kidney | 0.5 | Not detected |
| Small intestine | 0.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung carcinoma) | 8.7 | High expression |
| NCI-H460 (large cell lung cancer) | 6.2 | Medium expression |
| HepG2 (hepatocellular carcinoma) | 0.4 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1Val) | Missense | <0.01% | Likely loss of function |
| c.337C>T (p.Arg113Trp) | Missense | <0.01% | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
c.1A>G (p.Met1Val) likely disrupts translation initiation.
Gain of Function (GOF)
No gain-of-function variants reported.
Dominant Negative (DN)
No dominant-negative variants reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Metabolism of xenobiotics by cytochrome P450 (KEGG: hsa00980)
• Chemical carcinogenesis (KEGG: hsa05204)
• Drug metabolism - cytochrome P450 (KEGG: hsa00982)
Protein Summary
CYP2F1 is a 491-amino-acid microsomal cytochrome P450 monooxygenase predominantly expressed in the lung. It catalyzes the oxidative metabolism of small hydrophobic substrates such as naphthalene, styrene, and ethoxycoumarin. The enzyme plays a key role in the bioactivation of pulmonary toxicants and is implicated in chemical-induced lung injury and carcinogenesis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CYP2F1 Knockout HEK293 Cell Line | EDJ-KQ3671 | Human | 1572 | Details Get a Quote |
| CYP2F1 Knockout HeLa Cell Line | EDJ-KQ53051 | Human | 1572 | Details Get a Quote |
| CYP2F1 Knockout A-549 Cell Line | EDJ-KQ61516 | Human | 1572 | Details Get a Quote |
| CYP2F1 Knockout HCT 116 Cell Line | EDJ-KQ70009 | Human | 1572 | Details Get a Quote |
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