CXorf66
Chromosome X Open Reading Frame 66
Gene Information Card
| Symbol | CXorf66 |
|---|---|
| Full Name | Chromosome X Open Reading Frame 66 |
| Gene Type | Protein-coding |
| Chromosomal Location | Xq28 |
| NCBI Gene ID | 347735 ncbi.nlm.nih.gov/gene/347735 |
| Ensembl ID | ENSG00000147140 |
| UniProt ID | Q8N6T3 |
| OMIM ID | 300946 |
| HGNC ID | 26437 |
| Aliases | FLJ32743 |
Description
CXorf66 is a protein-coding gene located on chromosome Xq28. The encoded protein has no well-characterized function and is not associated with any known disease in major databases. Expression data from GTEx and other sources indicate low to moderate expression in several tissues, but its biological role remains largely uncharacterized.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No known disease associations | Not applicable | No evidence in OMIM, ClinVar, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 2.1 | Low |
| Brain | 1.5 | Low |
| Lung | 1.2 | Low |
| Kidney | 0.9 | Low |
| Liver | 0.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 1.8 | Low expression |
| HeLa | 1.1 | Low expression |
| K562 | 0.7 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Protein Summary
The CXorf66 protein (UniProt Q8N6T3) is a 148-amino acid polypeptide with no known domains or functional motifs. Its function is uncharacterized, and no protein-protein interactions or enzymatic activities have been reported.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CXorf66 Knockout HEK293 Cell Line | EDJ-KQ13066 | Human | 347487 | Details Get a Quote |
| CXorf66 Knockout HeLa Cell Line | EDJ-KQ59817 | Human | 347487 | Details Get a Quote |
| CXorf66 Knockout A-549 Cell Line | EDJ-KQ68286 | Human | 347487 | Details Get a Quote |
| CXorf66 Knockout HCT 116 Cell Line | EDJ-KQ76660 | Human | 347487 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
