CXCR2
C-X-C Motif Chemokine Receptor 2
Gene Information Card
| Symbol | CXCR2 |
|---|---|
| Full Name | C-X-C Motif Chemokine Receptor 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 2q35 |
| NCBI Gene ID | 3579 ncbi.nlm.nih.gov/gene/3579 |
| Ensembl ID | ENSG00000180871 |
| UniProt ID | P25025 |
| OMIM ID | 146928 |
| HGNC ID | 2543 |
| Aliases | IL8RB, CD182, CMKAR2, IL8R2, CDw128b |
Description
CXCR2 encodes a G-protein-coupled receptor for C-X-C chemokines, including interleukin-8 (CXCL8). It mediates neutrophil chemotaxis, angiogenesis, and inflammatory responses. The receptor is expressed on neutrophils, monocytes, and some cancer cells, and is involved in tumor progression and metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Chronic Obstructive Pulmonary Disease (COPD) | CXCR2 mediates neutrophil recruitment to airways; overexpression contributes to inflammation and tissue damage. | NCBI Gene, OMIM |
| Melanoma | CXCR2 signaling promotes tumor growth, angiogenesis, and metastasis via CXCL8 binding. | COSMIC, NCBI Gene |
| Atherosclerosis | CXCR2 on monocytes/macrophages facilitates vascular inflammation and plaque formation. | NCBI Gene, OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone Marrow | 12.5 | Medium |
| Spleen | 8.3 | Medium |
| Lung | 6.1 | Low |
| Whole Blood | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HL-60 (promyeloblast) | 15.2 | High expression; used in neutrophil differentiation studies |
| THP-1 (monocyte) | 10.1 | Medium expression; responsive to CXCL8 |
| A549 (lung carcinoma) | 3.5 | Low expression; upregulated in inflammation |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.926C>T (p.Ser309Leu) | Missense | <0.01% | Alters ligand binding affinity; associated with altered chemotaxis |
| c.1000G>A (p.Val334Ile) | Missense | <0.01% | Reduced receptor internalization; potential gain-of-function |
Mutation functional classification
Loss of Function (LOF)
Mutations impairing G-protein coupling or ligand binding reduce chemotactic response.
Gain of Function (GOF)
Variants enhancing receptor stability or signaling increase neutrophil recruitment and inflammation.
Dominant Negative (DN)
Not well documented for CXCR2.
View complete mutation data：
Gene Ontology (GO)
Pathways
• IL-8 Signaling Pathway (Reactome: R-HSA-6783783)
• Chemokine Signaling Pathway (KEGG: hsa04062)
• Neutrophil Degranulation (Reactome: R-HSA-6798695)
Protein Summary
CXCR2 is a 360-amino acid transmembrane receptor that binds CXCL8 (IL-8) and other CXC chemokines. It activates downstream pathways including PI3K/AKT and MAPK, leading to neutrophil chemotaxis, degranulation, and angiogenesis. The receptor is a therapeutic target in inflammatory diseases and cancer.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CXCR2 Knockout HEK293 Cell Line | EDJ-KQ271 | Human | 3579 | Details Get a Quote |
| CXCR2 Knockout HeLa Cell Line | EDJ-KQ53642 | Human | 3579 | Details Get a Quote |
| CXCR2 Knockout A-549 Cell Line | EDJ-KQ62117 | Human | 3579 | Details Get a Quote |
| CXCR2 Knockout HCT 116 Cell Line | EDJ-KQ70606 | Human | 3579 | Details Get a Quote |
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