CXCR1: C-X-C Motif Chemokine Receptor 1
Key mediator of neutrophil chemotaxis and inflammatory response
Gene Information Card
| Symbol | CXCR1 |
|---|---|
| Full Name | C-X-C Motif Chemokine Receptor 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 2q35 |
| NCBI Gene ID | 3577 ncbi.nlm.nih.gov/gene/3577 |
| Ensembl ID | ENSG00000163464 |
| UniProt ID | P25024 |
| OMIM ID | 146929 |
| HGNC ID | 6026 |
| Aliases | IL8RA, CD128, CKR-1, CMKAR1, CDw128a |
Description
CXCR1 encodes a G protein-coupled receptor for interleukin-8 (IL-8/CXCL8). It is primarily expressed on neutrophils and mediates chemotaxis, degranulation, and respiratory burst in response to infection and inflammation. The receptor also binds CXCL6 and plays roles in angiogenesis and tumor progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Chronic Obstructive Pulmonary Disease (COPD) | CXCR1 signaling promotes neutrophil recruitment and airway inflammation | PMID: 20628007 |
| Breast Cancer | CXCR1/2 signaling supports cancer stem cell survival and metastasis | PMID: 20453831 |
| HIV-1 Infection | CXCR1 polymorphisms influence susceptibility to HIV-1 and disease progression | PMID: 15674384 |
| Rheumatoid Arthritis | CXCR1-mediated neutrophil infiltration contributes to joint inflammation | PMID: 18317592 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone Marrow | 12.3 | Medium |
| Spleen | 8.7 | Medium |
| Lung | 6.5 | Low |
| Blood | 15.1 | High |
| Small Intestine | 4.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HL-60 (promyeloblast) | 18.5 | Differentiated to neutrophil-like cells |
| THP-1 (monocyte) | 9.8 | Low expression; upregulated upon differentiation |
| K-562 (erythroleukemia) | 2.1 | Minimal expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.260C>T (p.Ser87Leu) | Missense | 0.01% (gnomAD) | Reduced ligand binding affinity |
| c.819C>T (p.Arg273Cys) | Missense | 0.005% (gnomAD) | Impaired receptor internalization |
| c.1000G>A (p.Gly334Ser) | Missense | 0.02% (gnomAD) | Altered chemotactic response |
Mutation functional classification
Loss of Function (LOF)
c.260C>T (p.Ser87Leu) reduces IL-8 binding and downstream signaling.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in CXCR1.
Dominant Negative (DN)
c.819C>T (p.Arg273Cys) may exert dominant-negative effects by impairing receptor recycling.
View complete mutation data：
Gene Ontology (GO)
Pathways
• IL-8 signaling pathway (Reactome: R-HSA-6783783)
• Chemokine receptors bind chemokines (Reactome: R-HSA-380108)
• Neutrophil degranulation (Reactome: R-HSA-6798695)
• GPCR downstream signaling (Reactome: R-HSA-388396)
Protein Summary
CXCR1 is a 350-amino acid transmembrane protein belonging to the rhodopsin-like GPCR family. It contains seven transmembrane domains and an N-terminal extracellular region critical for IL-8 binding. Upon ligand activation, it couples to Gi proteins, activating PI3K, MAPK, and PLC pathways, leading to calcium mobilization, actin reorganization, and chemotaxis. CXCR1 is highly expressed on neutrophils and is essential for acute inflammatory responses.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CXCR1 Knockout HEK293 Cell Line | EDJ-KQ1723 | Human | 3577 | Details Get a Quote |
| CXCR1 Knockout HeLa Cell Line | EDJ-KQ53640 | Human | 3577 | Details Get a Quote |
| CXCR1 Knockout A-549 Cell Line | EDJ-KQ62115 | Human | 3577 | Details Get a Quote |
| CXCR1 Knockout HCT 116 Cell Line | EDJ-KQ70604 | Human | 3577 | Details Get a Quote |
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