CXCL6: C-X-C Motif Chemokine Ligand 6
Chemokine Involved in Inflammation, Angiogenesis, and Tumorigenesis
Gene Information Card
| Symbol | CXCL6 |
|---|---|
| Full Name | C-X-C Motif Chemokine Ligand 6 |
| Gene Type | Protein coding |
| Chromosomal Location | 4q13.3 |
| NCBI Gene ID | 6372 ncbi.nlm.nih.gov/gene/6372 |
| Ensembl ID | ENSG00000124875 |
| UniProt ID | P80162 |
| OMIM ID | 138965 |
| HGNC ID | 10643 |
| Aliases | GCP-2, CKA-3, SCYB6 |
Description
CXCL6 (C-X-C Motif Chemokine Ligand 6) is a chemokine gene encoding a small cytokine belonging to the CXC chemokine family. The encoded protein, granulocyte chemotactic protein 2 (GCP-2), is a potent chemoattractant for neutrophils and plays a key role in inflammatory responses, angiogenesis, and tumor progression. CXCL6 signals through the chemokine receptors CXCR1 and CXCR2.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Inflammatory bowel disease | CXCL6 overexpression recruits neutrophils to intestinal mucosa, exacerbating inflammation | PMID: 21559306 |
| Rheumatoid arthritis | Elevated CXCL6 in synovial fluid promotes neutrophil infiltration and joint destruction | PMID: 12070119 |
| Non-small cell lung cancer | CXCL6 promotes tumor angiogenesis and metastasis via CXCR2 signaling | PMID: 26921324 |
| Colorectal cancer | CXCL6 expression correlates with poor prognosis and promotes epithelial-mesenchymal transition | PMID: 29593339 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone marrow | 12.5 | Medium |
| Lung | 8.3 | Medium |
| Spleen | 6.1 | Low |
| Small intestine | 5.4 | Low |
| Colon | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 15.2 | Stimulated with LPS |
| A549 (lung carcinoma) | 9.7 | Basal expression |
| HUVEC (endothelial) | 7.1 | TNF-alpha induced |
| HT-29 (colorectal adenocarcinoma) | 6.3 | Constitutive |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | <0.01% | Unknown functional effect |
| c.205G>A (p.Gly69Ser) | Missense | <0.01% | Reported in COSMIC (COSV101234567) |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC for CXCL6.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported; overexpression is primarily transcriptional.
Dominant Negative (DN)
No dominant-negative mutations described for CXCL6.
View complete mutation data：
Gene Ontology (GO)
Pathways
• IL-17 signaling pathway (KEGG: hsa04657)
• Chemokine signaling pathway (KEGG: hsa04062)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• NF-kappa B signaling pathway (KEGG: hsa04064)
Protein Summary
CXCL6 (GCP-2) is a 114-amino-acid secreted chemokine with a typical CXC motif. It binds to CXCR1 and CXCR2 receptors, mediating neutrophil chemotaxis, degranulation, and angiogenesis. The protein is involved in acute and chronic inflammation, wound healing, and tumor progression. Post-translational processing includes signal peptide cleavage and disulfide bond formation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CXCL6 Knockout HEK293 Cell Line | EDJ-KQ1479 | Human | 6372 | Details Get a Quote |
| CXCL6 Knockout HeLa Cell Line | EDJ-KQ54432 | Human | 6372 | Details Get a Quote |
| CXCL6 Knockout A-549 Cell Line | EDJ-KQ62920 | Human | 6372 | Details Get a Quote |
| CXCL6 Knockout HCT 116 Cell Line | EDJ-KQ71389 | Human | 6372 | Details Get a Quote |
