CXCL5 (C-X-C Motif Chemokine Ligand 5)
Chemokine involved in neutrophil recruitment, inflammation, and cancer progression
Gene Information Card
| Symbol | CXCL5 |
|---|---|
| Full Name | C-X-C Motif Chemokine Ligand 5 |
| Gene Type | protein-coding |
| Chromosomal Location | 4q13.3 |
| NCBI Gene ID | 6374 ncbi.nlm.nih.gov/gene/6374 |
| Ensembl ID | ENSG00000163735 |
| UniProt ID | P42830 |
| OMIM ID | 600324 |
| HGNC ID | 4605 |
| Aliases | ENA-78, SCYB5, small inducible cytokine B5 |
Description
CXCL5 (C-X-C Motif Chemokine Ligand 5) is a chemokine gene that encodes a protein belonging to the CXC chemokine family. This protein is a potent chemoattractant for neutrophils, playing a key role in inflammatory responses and immune regulation. It is secreted by various cell types, including epithelial cells, macrophages, and tumor cells, and exerts its effects by binding to the chemokine receptor CXCR2. CXCL5 is involved in angiogenesis, wound healing, and has been implicated in several inflammatory diseases and cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | CXCL5 overexpression promotes tumor growth and metastasis via CXCR2 signaling, enhancing angiogenesis and neutrophil infiltration. | PMID: 25605247; COSMIC |
| Non-Small Cell Lung Cancer | Elevated CXCL5 levels correlate with poor prognosis; it recruits neutrophils to the tumor microenvironment, facilitating immune evasion. | PMID: 26928204; ClinVar |
| Rheumatoid Arthritis | CXCL5 is upregulated in synovial fluid, attracting neutrophils to joints and contributing to chronic inflammation. | PMID: 11590182; OMIM 600324 |
| Chronic Obstructive Pulmonary Disease (COPD) | Increased CXCL5 expression in airway epithelium drives neutrophil-mediated inflammation and tissue damage. | PMID: 20851989; NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | High |
| Colon | 8.3 | Medium |
| Liver | 6.1 | Medium |
| Spleen | 4.7 | Low |
| Kidney | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (Lung Cancer) | 15.8 | High expression; used in studies of CXCL5-mediated inflammation |
| HCT116 (Colorectal Cancer) | 9.4 | Moderate expression; associated with metastatic potential |
| THP-1 (Monocyte) | 2.1 | Low baseline; inducible by LPS stimulation |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1Val) | Missense | <0.1% | Likely affects translation initiation; rare in population databases |
| c.214C>T (p.Arg72Cys) | Missense | 0.2% | May alter protein stability; reported in COSMIC for colorectal cancer |
| c.337G>A (p.Gly113Ser) | Missense | 0.05% | Unknown functional impact; observed in lung cancer samples |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in CXCL5.
Gain of Function (GOF)
Overexpression or amplification of CXCL5 is common in cancers, leading to enhanced chemokine signaling and tumor progression.
Dominant Negative (DN)
No dominant-negative mutations have been described for CXCL5.
View complete mutation data：
Gene Ontology (GO)
Pathways
• IL-17 signaling pathway (KEGG hsa04657)
• Chemokine signaling pathway (KEGG hsa04062)
• TNF signaling pathway (KEGG hsa04668)
• NF-kappa B signaling pathway (KEGG hsa04064)
Protein Summary
The CXCL5 protein, also known as ENA-78, is a 114-amino-acid chemokine with a characteristic CXC motif. It is secreted as a monomer and binds to the G-protein-coupled receptor CXCR2. The protein is involved in neutrophil recruitment, angiogenesis, and tissue remodeling. Its expression is induced by pro-inflammatory cytokines such as IL-1 and TNF-alpha. In cancer, CXCL5 promotes tumor growth and metastasis by modulating the tumor microenvironment.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CXCL5 Knockout HEK293 Cell Line | EDJ-KQ1478 | Human | 6374 | Details Get a Quote |
| CXCL5 Knockout A-549 Cell Line | EDJ-KQ21062 | Human | 6374 | Details Get a Quote |
| CXCL5 Knockout HeLa Cell Line | EDJ-KQ21063 | Human | 6374 | Details Get a Quote |
| CXCL5 Knockout HCT 116 Cell Line | EDJ-KQ71391 | Human | 6374 | Details Get a Quote |
