CXCL3: C-X-C Motif Chemokine Ligand 3
A chemokine involved in inflammation, angiogenesis, and tumorigenesis
Gene Information Card
| Symbol | CXCL3 |
|---|---|
| Full Name | C-X-C Motif Chemokine Ligand 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 4q13.3 |
| NCBI Gene ID | 2921 ncbi.nlm.nih.gov/gene/2921 |
| Ensembl ID | ENSG00000163737 |
| UniProt ID | P19876 |
| OMIM ID | 139111 |
| HGNC ID | 4604 |
| Aliases | GRO3, GRO gamma, MIP-2B, SCYB3, CINC-2b |
Description
CXCL3 (C-X-C Motif Chemokine Ligand 3) is a member of the CXC chemokine family. It encodes a secreted protein that binds to the chemokine receptor CXCR2. CXCL3 functions as a chemoattractant for neutrophils and other immune cells, playing a key role in inflammation, wound healing, and angiogenesis. Overexpression is associated with various cancers and inflammatory diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Inflammatory bowel disease | CXCL3 recruits neutrophils to inflamed intestinal mucosa via CXCR2 | PMID: 23470731 |
| Colorectal cancer | CXCL3 promotes tumor growth and angiogenesis through CXCR2 signaling | PMID: 25964219 |
| Breast cancer | CXCL3 expression correlates with metastasis and poor prognosis | PMID: 27397505 |
| Rheumatoid arthritis | CXCL3 mediates neutrophil infiltration into synovial tissue | PMID: 12882850 |
| Psoriasis | Elevated CXCL3 levels in skin lesions contribute to chronic inflammation | PMID: 17641037 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone marrow | 0.8 | Low |
| Lung | 1.2 | Low |
| Spleen | 2.5 | Medium |
| Lymph node | 3.1 | Medium |
| Colon | 4.0 | Medium |
| Small intestine | 3.5 | Medium |
| Appendix | 5.2 | High |
| Tonsil | 6.0 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 8.5 | High expression after LPS stimulation |
| HeLa (cervical cancer) | 2.3 | Moderate expression |
| A549 (lung cancer) | 1.8 | Low expression |
| HUVEC (endothelial) | 4.7 | Induced by TNF-alpha |
| MCF-7 (breast cancer) | 3.0 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T | Missense | 0.01% | p.Thr34Ile; unknown functional impact |
| c.205G>A | Missense | 0.005% | p.Gly69Ser; predicted benign |
| c.298A>G | Missense | 0.002% | p.Asn100Asp; no known disease association |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in CXCL3.
Gain of Function (GOF)
Overexpression in tumors suggests potential gain-of-function via increased chemotaxis and angiogenesis.
Dominant Negative (DN)
Not described for CXCL3.
View complete mutation data：
Gene Ontology (GO)
Pathways
• IL-17 signaling pathway (KEGG: hsa04657)
• Chemokine signaling pathway (KEGG: hsa04062)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• TNF signaling pathway (KEGG: hsa04668)
• NF-kappa B signaling pathway (KEGG: hsa04064)
Protein Summary
CXCL3 is a 107-amino acid secreted chemokine (UniProt P19876) with a typical CXC motif (Cys-X-Cys). It forms homodimers and binds to the G protein-coupled receptor CXCR2. The protein is involved in neutrophil recruitment, angiogenesis, and tumor progression. Post-translational modifications include signal peptide cleavage (residues 1-34) and disulfide bond formation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CXCL3 Knockout HEK293 Cell Line | EDJ-KQ50318 | Human | 2921 | Details Get a Quote |
| CXCL3 Knockout HeLa Cell Line | EDJ-KQ53444 | Human | 2921 | Details Get a Quote |
| CXCL3 Knockout A-549 Cell Line | EDJ-KQ61918 | Human | 2921 | Details Get a Quote |
| CXCL3 Knockout HCT 116 Cell Line | EDJ-KQ70398 | Human | 2921 | Details Get a Quote |
