CXCL17: Chemokine (C-X-C Motif) Ligand 17
A secreted chemokine with roles in mucosal immunity, angiogenesis, and tumor biology.
Gene Information Card
| Symbol | CXCL17 |
|---|---|
| Full Name | C-X-C Motif Chemokine Ligand 17 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.2 |
| NCBI Gene ID | 284340 ncbi.nlm.nih.gov/gene/284340 |
| Ensembl ID | ENSG00000189334 |
| UniProt ID | Q6UXB2 |
| OMIM ID | 611387 |
| HGNC ID | 24801 |
| Aliases | VCC-1, DMC, UNQ473 |
Description
CXCL17 (C-X-C Motif Chemokine Ligand 17) is a secreted chemokine that functions in mucosal immunity, angiogenesis, and tumor biology. It is expressed in mucosal tissues (lung, stomach, colon) and acts as a chemoattractant for monocytes, macrophages, and dendritic cells. CXCL17 is also implicated in tumor progression and metastasis, with overexpression observed in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | Overexpression of CXCL17 promotes tumor growth and angiogenesis via recruitment of myeloid-derived suppressor cells (MDSCs). | PMID: 25934862 |
| Gastric Cancer | CXCL17 is upregulated in gastric cancer tissues and correlates with poor prognosis, potentially through immune evasion mechanisms. | PMID: 27323851 |
| Lung Cancer | CXCL17 expression is elevated in non-small cell lung cancer (NSCLC) and associated with increased microvessel density. | PMID: 23149921 |
| Inflammatory Bowel Disease | CXCL17 is downregulated in ulcerative colitis mucosa, suggesting a role in mucosal homeostasis. | PMID: 21880725 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Stomach | 8.3 | Medium |
| Colon | 6.1 | Low |
| Small Intestine | 5.4 | Low |
| Trachea | 4.8 | Low |
| Esophagus | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (Lung adenocarcinoma) | 15.2 | High expression |
| MCF7 (Breast cancer) | 2.1 | Low expression |
| HeLa (Cervical cancer) | 1.8 | Low expression |
| HCT116 (Colorectal carcinoma) | 7.4 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.1% | Potential loss of start codon; functional impact unknown |
| c.214C>T (p.Arg72Trp) | Missense | <0.1% | Rare variant; no known disease association |
| c.331G>A (p.Gly111Ser) | Missense | <0.1% | Rare variant; no known disease association |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in CXCL17.
Gain of Function (GOF)
Overexpression in tumors suggests potential gain-of-function in cancer contexts.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • chemokine activity (GO:0008009) | • extracellular region (GO:0005576) |
| • immune response (GO:0006955) | • chemotaxis (GO:0006935) |
| • lymphocyte chemotaxis (GO:0048247) | • angiogenesis (GO:0001525) |
Pathways
• Chemokine signaling pathway (KEGG: hsa04062)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
Protein Summary
CXCL17 is a 119-amino acid secreted chemokine containing a C-X-C motif. It is structurally distinct from other chemokines and is highly conserved in mammals. The protein is involved in recruiting immune cells to mucosal surfaces and promoting angiogenesis. Its expression is regulated by inflammatory stimuli and is frequently dysregulated in cancer.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CXCL17 Knockout HEK293 Cell Line | EDJ-KQ13059 | Human | 284340 | Details Get a Quote |
| CXCL17 Knockout HeLa Cell Line | EDJ-KQ59452 | Human | 284340 | Details Get a Quote |
| CXCL17 Knockout A-549 Cell Line | EDJ-KQ67916 | Human | 284340 | Details Get a Quote |
| CXCL17 Knockout HCT 116 Cell Line | EDJ-KQ76295 | Human | 284340 | Details Get a Quote |
