CTTN Gene (Cortactin)
Actin-binding protein involved in cell migration and cancer metastasis
Gene Information Card
| Symbol | CTTN |
|---|---|
| Full Name | Cortactin |
| Gene Type | Protein coding |
| Chromosomal Location | 11q13.3 |
| NCBI Gene ID | 2017 ncbi.nlm.nih.gov/gene/2017 |
| Ensembl ID | ENSG00000085733 |
| UniProt ID | Q14247 |
| OMIM ID | 164765 |
| HGNC ID | 2498 |
| Aliases | EMS1, FLJ34459 |
Description
The CTTN gene encodes cortactin, a cytoskeletal protein that binds to actin filaments and regulates cell motility, adhesion, and invasion. It is frequently amplified in various cancers, contributing to metastatic potential.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Amplification and overexpression of CTTN enhance cell migration and invasion | PMID: 10655551 |
| Head and neck squamous cell carcinoma | CTTN amplification correlates with poor prognosis and metastasis | PMID: 17047042 |
| Esophageal squamous cell carcinoma | CTTN overexpression promotes tumor progression and lymph node metastasis | PMID: 19029980 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Breast | 10.2 | Medium |
| Colon | 8.9 | Low |
| Liver | 6.3 | Low |
| Brain | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 | 15.3 | Breast cancer cell line |
| HeLa | 18.7 | Cervical cancer cell line |
| A549 | 14.1 | Lung cancer cell line |
| HepG2 | 9.8 | Liver cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1245G>A | Missense | <0.1% | Unknown functional effect |
| c.789_790insC | Frameshift | <0.1% | Predicted loss of function |
| Amplification | Copy number gain | Common in cancers | Increased expression and oncogenic activity |
Mutation functional classification
Loss of Function (LOF)
Rare frameshift mutations may reduce cortactin protein levels, impairing actin dynamics.
Gain of Function (GOF)
Gene amplification and overexpression enhance cell migration and invasion, acting as an oncogenic driver.
Dominant Negative (DN)
Not well documented for CTTN.
View complete mutation data：
Gene Ontology (GO)
| • actin binding | • cell migration |
| • lamellipodium assembly | • protein phosphorylation |
| • signal transduction |
Pathways
• Regulation of actin cytoskeleton
• Focal adhesion
• EGFR signaling pathway
• Rac1 signaling
Protein Summary
Cortactin is a 550-amino acid protein that contains an N-terminal acidic domain, a central repeat region, and a C-terminal SH3 domain. It promotes actin polymerization by activating the Arp2/3 complex and stabilizes branched actin networks, playing a key role in cell protrusion and invasion.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CTTN Knockout HEK293 Cell Line | EDJ-KQ2568 | Human | 2017 | Details Get a Quote |
| CTTNBP2 Knockout HEK293 Cell Line | EDJ-KQ9955 | Human | 83992 | Details Get a Quote |
| CTTNBP2NL Knockout HEK293 Cell Line | EDJ-KQ13052 | Human | 55917 | Details Get a Quote |
| CTTN Knockout A-549 Cell Line | EDJ-KQ23243 | Human | 2017 | Details Get a Quote |
| CTTN Knockout HCT 116 Cell Line | EDJ-KQ23244 | Human | 2017 | Details Get a Quote |
| CTTN Knockout HeLa Cell Line | EDJ-KQ23245 | Human | 2017 | Details Get a Quote |
| CTTNBP2 Knockout HCT 116 Cell Line | EDJ-KQ36871 | Human | 83992 | Details Get a Quote |
| CTTNBP2NL Knockout A-549 Cell Line | EDJ-KQ42325 | Human | 55917 | Details Get a Quote |
| CTTNBP2NL Knockout HCT 116 Cell Line | EDJ-KQ42326 | Human | 55917 | Details Get a Quote |
| CTTNBP2NL Knockout HeLa Cell Line | EDJ-KQ42327 | Human | 55917 | Details Get a Quote |
| CTTNBP2 Knockout HeLa Cell Line | EDJ-KQ57517 | Human | 83992 | Details Get a Quote |
| CTTNBP2 Knockout A-549 Cell Line | EDJ-KQ66017 | Human | 83992 | Details Get a Quote |
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