CTRC Gene: Chymotrypsin C (Caldecrin)
A serine protease involved in pancreatic function and associated with pancreatitis and cancer.
Gene Information Card
| Symbol | CTRC |
|---|---|
| Full Name | Chymotrypsin C (caldecrin) |
| Gene Type | protein-coding |
| Chromosomal Location | 1p36.21 |
| NCBI Gene ID | 11330 ncbi.nlm.nih.gov/gene/11330 |
| Ensembl ID | ENSG00000162572 |
| UniProt ID | Q99895 |
| OMIM ID | 601405 |
| HGNC ID | 2523 |
| Aliases | CLCR, ELA4, caldecrin |
Description
The CTRC gene encodes chymotrypsin C, a calcium-dependent serine protease secreted by the pancreas. It plays a key role in digestive enzyme activation and regulation, and mutations are linked to chronic pancreatitis and pancreatic cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Chronic Pancreatitis | Loss-of-function mutations reduce trypsin degradation, leading to premature trypsin activation and autodigestion. | ClinVar, OMIM |
| Pancreatic Cancer | Somatic mutations and altered expression may contribute to tumor progression. | COSMIC, NCBI |
| Tropical Calcific Pancreatitis | Genetic variants in CTRC increase susceptibility. | OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Pancreas | 189.2 | High |
| Salivary Gland | 1.5 | Low |
| Stomach | 0.8 | Low |
| Duodenum | 0.6 | Low |
| Liver | 0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PANC-1 | 45.3 | Pancreatic cancer cell line |
| MIA PaCa-2 | 38.7 | Pancreatic cancer cell line |
| BxPC-3 | 52.1 | Pancreatic cancer cell line |
| HEK 293 | 0.2 | Non-pancreatic control |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.180C>T (p.Gly60Gly) | synonymous | 0.1% | Likely benign |
| c.703G>A (p.Gly235Ser) | missense | 0.5% | Associated with chronic pancreatitis |
| c.760C>T (p.Arg254Trp) | missense | 0.3% | Loss of function, pancreatitis risk |
| c.486_487del (p.Lys162Asnfs*5) | frameshift | 0.01% | Loss of function, severe pancreatitis |
Mutation functional classification
Loss of Function (LOF)
Common in chronic pancreatitis; reduces trypsin degradation activity.
Gain of Function (GOF)
Not reported for CTRC.
Dominant Negative (DN)
Not reported for CTRC.
View complete mutation data：
Gene Ontology (GO)
| • serine-type endopeptidase activity (GO:0004252) | • proteolysis (GO:0006508) |
| • extracellular space (GO:0005615) | • extracellular matrix (GO:0031012) |
| • hydrolase activity (GO:0016787) |
Pathways
• Digestion and absorption of proteins (Reactome: R-HSA-8963748)
• Pancreatic secretion (KEGG: hsa04972)
Protein Summary
Chymotrypsin C (caldecrin) is a 268-amino acid serine protease synthesized in the pancreas and secreted as an inactive zymogen. It is activated by trypsin and functions to degrade trypsin and other digestive enzymes, thereby protecting the pancreas from autodigestion. Its calcium-binding property distinguishes it from other chymotrypsins.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CTRC Knockout HEK293 Cell Line | EDJ-KQ7374 | Human | 11330 | Details Get a Quote |
| CTRC Knockout HeLa Cell Line | EDJ-KQ55632 | Human | 11330 | Details Get a Quote |
| CTRC Knockout A-549 Cell Line | EDJ-KQ64130 | Human | 11330 | Details Get a Quote |
| CTRC Knockout HCT 116 Cell Line | EDJ-KQ72575 | Human | 11330 | Details Get a Quote |
