CTIF
CBP80/20-dependent translation initiation factor
Gene Information Card
| Symbol | CTIF |
|---|---|
| Full Name | CBP80/20-dependent translation initiation factor |
| Gene Type | protein-coding |
| Chromosomal Location | 18p11.21 |
| NCBI Gene ID | 9810 ncbi.nlm.nih.gov/gene/9810 |
| Ensembl ID | ENSG00000101473 |
| UniProt ID | Q9H3Z4 |
| OMIM ID | 616534 |
| HGNC ID | 24269 |
| Aliases | CBCP, KIAA0426, CBP80/20-dependent translation initiation factor |
Description
CTIF encodes a protein that functions as a translation initiation factor specifically for mRNAs that have undergone nonsense-mediated decay (NMD) and are bound by the cap-binding complex (CBC). It promotes the first round of translation by interacting with the CBC and the 40S ribosomal subunit, facilitating the transition from the pioneer round of translation to steady-state translation. CTIF is involved in mRNA surveillance and quality control pathways.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | No curated disease entries in OMIM, ClinVar, or COSMIC as of current data |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Brain | 8.5 | Low |
| Lung | 6.2 | Low |
| Liver | 5.1 | Low |
| Kidney | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.1 | Moderate expression |
| HeLa | 7.4 | Low expression |
| K562 | 6.9 | Low expression |
| A549 | 5.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No recurrent mutations reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No functional data available
Gain of Function (GOF)
No functional data available
Dominant Negative (DN)
No functional data available
View complete mutation data：
Gene Ontology (GO)
| • translation initiation factor activity (GO:0003743) | • cytoplasm (GO:0005737) |
| • cytosol (GO:0005829) | • translational initiation (GO:0006413) |
| • nuclear-transcribed mRNA catabolic process (GO:0000184) |
Pathways
• Nonsense-mediated decay (NMD) pathway
• mRNA surveillance pathway
Protein Summary
The CTIF protein (UniProt Q9H3Z4) is 598 amino acids long and contains an N-terminal domain that interacts with the cap-binding complex (CBC) and a C-terminal domain that binds the 40S ribosomal subunit. It is essential for the pioneer round of translation of NMD-targeted mRNAs, ensuring proper mRNA quality control. The protein is ubiquitously expressed at low levels, with highest expression in testis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CTIF Knockout HEK293 Cell Line | EDJ-KQ6755 | Human | 9811 | Details Get a Quote |
| CTIF Knockout A-549 Cell Line | EDJ-KQ31180 | Human | 9811 | Details Get a Quote |
| CTIF Knockout HCT 116 Cell Line | EDJ-KQ31181 | Human | 9811 | Details Get a Quote |
| CTIF Knockout HeLa Cell Line | EDJ-KQ31182 | Human | 9811 | Details Get a Quote |
