CST11 (Cystatin 11)
A cysteine protease inhibitor involved in male reproductive function and potential tumor suppression.
Gene Information Card
| Symbol | CST11 |
|---|---|
| Full Name | Cystatin 11 |
| Gene Type | Protein coding |
| Chromosomal Location | 20p11.21 |
| NCBI Gene ID | 140881 ncbi.nlm.nih.gov/gene/140881 |
| Ensembl ID | ENSG00000125869 |
| UniProt ID | Q9H112 |
| OMIM ID | 609345 |
| HGNC ID | 2473 |
| Aliases | CST11, cystatin 11, cystatin-11, CST11_HUMAN |
Description
CST11 encodes cystatin 11, a member of the type 2 cystatin family of cysteine protease inhibitors. The protein is primarily expressed in the male reproductive tract, particularly in the epididymis and seminal vesicles, where it inhibits cysteine proteases involved in semen liquefaction and sperm maturation. CST11 may also play a role in tumor suppression, with reduced expression observed in prostate cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate Cancer | Reduced CST11 expression may contribute to tumor progression by altering protease activity in the tumor microenvironment. | COSMIC, ClinVar |
| Male Infertility | Dysregulation of CST11 may affect semen liquefaction and sperm function, though direct evidence is limited. | OMIM, UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Epididymis | 12.5 | Medium |
| Seminal Vesicle | 8.3 | Low |
| Prostate | 2.1 | Low |
| Testis | 1.5 | Not detected |
| Kidney | 0.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PC-3 (prostate cancer) | 0.8 | Low expression |
| LNCaP (prostate cancer) | 0.5 | Low expression |
| HEK293 (embryonic kidney) | 0.1 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | p.Met1Val; potential loss of start codon |
| c.124C>T | Missense | <0.01% | p.Arg42Cys; may affect protein stability |
Mutation functional classification
Loss of Function (LOF)
Missense mutations at the start codon or conserved residues likely reduce protein expression or activity.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Cysteine protease inhibition in semen liquefaction
• Prostate cancer - altered protease activity
Protein Summary
Cystatin 11 is a 139-amino acid secreted protein containing a signal peptide and a cystatin domain. It inhibits cysteine proteases such as cathepsins, and is specifically expressed in the male reproductive tract. The protein is involved in regulating semen liquefaction by inhibiting proteases that cleave semenogelin. Reduced expression in prostate cancer suggests a potential tumor suppressor role.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CST11 Knockout HEK293 Cell Line | EDJ-KQ9829 | Human | 140880 | Details Get a Quote |
| CST11 Knockout HeLa Cell Line | EDJ-KQ58469 | Human | 140880 | Details Get a Quote |
| CST11 Knockout A-549 Cell Line | EDJ-KQ66956 | Human | 140880 | Details Get a Quote |
| CST11 Knockout HCT 116 Cell Line | EDJ-KQ75357 | Human | 140880 | Details Get a Quote |
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