CSPG5: Chondroitin Sulfate Proteoglycan 5
A key proteoglycan in neural development and synaptic function
Gene Information Card
| Symbol | CSPG5 |
|---|---|
| Full Name | chondroitin sulfate proteoglycan 5 |
| Gene Type | protein-coding |
| Chromosomal Location | 3p21.31 |
| NCBI Gene ID | 10675 ncbi.nlm.nih.gov/gene/10675 |
| Ensembl ID | ENSG00000114646 |
| UniProt ID | O95196 |
| OMIM ID | 608173 |
| HGNC ID | 2468 |
| Aliases | NG2, neuroglycan C, CALEB |
Description
CSPG5 (chondroitin sulfate proteoglycan 5), also known as neuroglycan C or CALEB, encodes a transmembrane proteoglycan predominantly expressed in the nervous system. It plays a critical role in neural development, neurite outgrowth, synaptic plasticity, and neuronal migration. The protein carries chondroitin sulfate chains and interacts with growth factors and extracellular matrix components.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Schizophrenia | Altered CSPG5 expression may disrupt synaptic signaling and neural connectivity | PMID: 21362589 |
| Bipolar disorder | Genetic association studies implicate CSPG5 variants in mood regulation pathways | PMID: 22472876 |
| Glioblastoma | Overexpression of CSPG5 promotes tumor cell invasion and proliferation | PMID: 25605247 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 45.2 | High |
| Cerebral cortex | 52.1 | High |
| Cerebellum | 38.7 | Medium |
| Spinal cord | 22.3 | Medium |
| Heart | 5.1 | Low |
| Liver | 1.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 62.4 | Neuronal model |
| U87MG (glioblastoma) | 48.9 | High expression |
| HEK293 (embryonic kidney) | 3.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.112G>A (p.Gly38Arg) | Missense | 0.01% | Unknown functional impact |
| c.457C>T (p.Arg153Trp) | Missense | 0.005% | Potential loss of function |
| c.789_790insA | Frameshift | 0.001% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations likely lead to truncated protein and loss of normal proteoglycan function.
Gain of Function (GOF)
No documented gain-of-function mutations in CSPG5.
Dominant Negative (DN)
No evidence of dominant-negative effects reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Chondroitin sulfate/dermatan sulfate metabolism (Reactome: R-HSA-1793185)
• ECM proteoglycans (KEGG: hsa04512)
• Neural crest differentiation (WikiPathways: WP2859)
Protein Summary
CSPG5 encodes a type I transmembrane proteoglycan (neuroglycan C) with an N-terminal chondroitin sulfate attachment domain, a single transmembrane helix, and a short cytoplasmic tail. The protein is heavily glycosylated and interacts with growth factors such as FGF2 and midkine, modulating neurite outgrowth and cell adhesion. It is predominantly expressed in the central nervous system and is implicated in neurodevelopmental disorders and glioblastoma.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CSPG5 Knockout HEK293 Cell Line | EDJ-KQ7128 | Human | 10675 | Details Get a Quote |
| CSPG5 Knockout A-549 Cell Line | EDJ-KQ32008 | Human | 10675 | Details Get a Quote |
| CSPG5 Knockout HCT 116 Cell Line | EDJ-KQ32009 | Human | 10675 | Details Get a Quote |
| CSPG5 Knockout HeLa Cell Line | EDJ-KQ30632 | Human | 10675 | Details Get a Quote |
