CSNK2A2: Casein Kinase 2 Alpha 2 Subunit
A key serine/threonine protein kinase involved in cell cycle control, DNA repair, and oncogenic signaling.
Gene Information Card
| Symbol | CSNK2A2 |
|---|---|
| Full Name | Casein Kinase 2 Alpha 2 Subunit |
| Gene Type | Protein coding |
| Chromosomal Location | 16p13.3 |
| NCBI Gene ID | 1459 ncbi.nlm.nih.gov/gene/1459 |
| Ensembl ID | ENSG00000102974 |
| UniProt ID | P19784 |
| OMIM ID | 115442 |
| HGNC ID | 2459 |
| Aliases | CK2A2, CK2alpha', CSNK2A1L |
Description
CSNK2A2 encodes the alpha' catalytic subunit of casein kinase 2 (CK2), a constitutively active serine/threonine protein kinase. CK2 phosphorylates a wide range of substrates involved in cell proliferation, apoptosis, circadian rhythm, and DNA damage response. The alpha' subunit is distinct from the alpha subunit (CSNK2A1) and is essential for embryonic development and hematopoiesis. Dysregulation of CSNK2A2 is implicated in various cancers and neurodegenerative disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Acute Myeloid Leukemia | Overexpression of CSNK2A2 promotes leukemic cell survival via phosphorylation of AKT and NF-κB pathways. | COSMIC; PMID: 25605248 |
| Breast Cancer | Amplification and overexpression of CSNK2A2 correlate with poor prognosis and tamoxifen resistance. | COSMIC; PMID: 21502514 |
| Colorectal Cancer | CK2 alpha' subunit drives Wnt/β-catenin signaling and tumor growth. | COSMIC; PMID: 23361059 |
| Neuroblastoma | High CSNK2A2 expression is associated with MYCN amplification and aggressive disease. | COSMIC; PMID: 24803658 |
| Prostate Cancer | CSNK2A2 knockdown reduces cell proliferation and induces apoptosis in androgen-independent cells. | COSMIC; PMID: 20628055 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 15.2 | Medium |
| Kidney | 10.1 | Medium |
| Testis | 20.4 | High |
| Lymph node | 18.7 | High |
| Bone marrow | 22.1 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 18.5 | Embryonic kidney; high expression |
| K562 | 21.3 | Leukemia; high expression |
| MCF7 | 14.2 | Breast cancer; medium expression |
| HepG2 | 16.8 | Liver cancer; medium expression |
| A549 | 12.0 | Lung cancer; medium expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| p.Glu7Lys | Missense | <0.01% | Unknown; likely benign |
| p.Arg47Trp | Missense | <0.01% | Unknown; reported in COSMIC |
| p.Thr128Ala | Missense | <0.01% | Unknown; COSMIC |
| p.Arg155Gln | Missense | <0.01% | Unknown; COSMIC |
| p.Arg191* | Nonsense | <0.01% | Loss of function; truncation |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., p.Arg191*) lead to truncated protein lacking kinase domain, reducing CK2 activity.
Gain of Function (GOF)
Missense mutations in the activation loop (e.g., p.Thr128Ala) may increase kinase activity, though evidence is limited.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported in CSNK2A2.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Wnt signaling pathway (KEGG: hsa04310)
• PI3K-Akt signaling pathway (KEGG: hsa04151)
• NF-kappa B signaling pathway (KEGG: hsa04064)
• DNA damage response (Reactome: R-HSA-73894)
• Circadian clock (Reactome: R-HSA-400253)
Protein Summary
The CSNK2A2 protein (UniProt P19784) is a 350-amino acid catalytic subunit of casein kinase 2 (CK2). It contains an N-terminal kinase domain (residues 1-300) and a C-terminal regulatory region. CK2 is a tetramer composed of two catalytic (alpha or alpha') and two regulatory (beta) subunits. The alpha' subunit is highly conserved and ubiquitously expressed, with highest levels in testis, bone marrow, and lymphoid tissues. It phosphorylates over 300 substrates, including p53, PTEN, and β-catenin, regulating cell survival, proliferation, and DNA repair. CK2 activity is often elevated in cancers, making it a therapeutic target.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CSNK2A2 Knockout HEK293 Cell Line | EDJ-KQ557 | Human | 1459 | Details Get a Quote |
| CSNK2A2IP Knockout HEK293 Cell Line | EDJ-KQ13018 | Human | 111064647 | Details Get a Quote |
| CSNK2A2 Knockout A-549 Cell Line | EDJ-KQ18028 | Human | 1459 | Details Get a Quote |
| CSNK2A2 Knockout HCT 116 Cell Line | EDJ-KQ18931 | Human | 1459 | Details Get a Quote |
| CSNK2A2 Knockout HeLa Cell Line | EDJ-KQ18932 | Human | 1459 | Details Get a Quote |
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