CRTAM Gene - Cytotoxic And Regulatory T Cell Molecule
Comprehensive gene card for CRTAM: function, expression, mutations, and associated diseases
Gene Information Card
| Symbol | CRTAM |
|---|---|
| Full Name | Cytotoxic And Regulatory T Cell Molecule |
| Gene Type | protein-coding |
| Chromosomal Location | 11q24.1 |
| NCBI Gene ID | 56253 ncbi.nlm.nih.gov/gene/56253 |
| Ensembl ID | ENSG00000149257 |
| UniProt ID | O95727 |
| OMIM ID | 606101 |
| HGNC ID | 2430 |
| Aliases | CD355, MGC138207 |
Description
CRTAM (Cytotoxic And Regulatory T Cell Molecule) encodes a type I transmembrane protein belonging to the nectin-like family of immunoglobulin-like receptors. It is expressed on activated T cells, natural killer (NK) cells, and certain dendritic cell subsets. CRTAM functions as a cell adhesion molecule and co-stimulatory receptor, promoting T cell activation, cytotoxicity, and cytokine production. Its ligand is Necl-2 (CADM1). CRTAM plays roles in immune surveillance, tumor immunity, and regulation of T cell responses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Inflammatory bowel disease (IBD) | CRTAM polymorphisms associated with altered T cell adhesion and activation | NCBI Gene, OMIM |
| Colorectal cancer | CRTAM expression correlates with tumor-infiltrating lymphocyte activity and prognosis | COSMIC, NCBI |
| Viral infections (e.g., HIV) | CRTAM upregulation on CD8+ T cells during chronic infection | NCBI, UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.8 | Medium |
| Small intestine | 8.2 | Low |
| Colon | 6.1 | Low |
| Lung | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Jurkat (T cell leukemia) | 15.2 | Activated T cell model |
| NK-92 (NK cell line) | 18.7 | High expression |
| THP-1 (monocytic) | 2.1 | Low expression |
| HeLa (cervical carcinoma) | 0.5 | Not expressed |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | <0.01% (gnomAD) | Unknown; predicted benign |
| c.487G>A (p.Gly163Ser) | Missense | <0.01% (gnomAD) | Unknown; predicted possibly damaging |
| c.1120_1121insA | Frameshift | Rare | Loss of function; truncated protein |
Mutation functional classification
Loss of Function (LOF)
Frameshift insertion c.1120_1121insA leads to premature stop codon and loss of transmembrane domain.
Gain of Function (GOF)
No gain-of-function mutations reported in COSMIC or ClinVar.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Immune System (Reactome R-HSA-168256)
• Cell adhesion molecules (CAMs) (KEGG hsa04514)
• Natural killer cell mediated cytotoxicity (KEGG hsa04650)
Protein Summary
CRTAM is a 389-amino acid type I transmembrane glycoprotein with an extracellular region containing one immunoglobulin-like V-type domain, a transmembrane segment, and a cytoplasmic tail with potential signaling motifs. It is predominantly expressed on activated CD8+ T cells, NK cells, and a subset of CD4+ T cells. Upon binding its ligand CADM1 (Necl-2), CRTAM enhances T cell adhesion, promotes IFN-gamma production, and supports cytotoxic activity. The protein is implicated in immune synapse formation and tumor immune surveillance.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CRTAM Knockout HEK293 Cell Line | EDJ-KQ13007 | Human | 56253 | Details Get a Quote |
| CRTAM Knockout HeLa Cell Line | EDJ-KQ56726 | Human | 56253 | Details Get a Quote |
| CRTAM Knockout A-549 Cell Line | EDJ-KQ65231 | Human | 56253 | Details Get a Quote |
| CRTAM Knockout HCT 116 Cell Line | EDJ-KQ73669 | Human | 56253 | Details Get a Quote |
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