CRHBP: Corticotropin Releasing Hormone Binding Protein
Key regulator of stress response and HPA axis activity
Gene Information Card
| Symbol | CRHBP |
|---|---|
| Full Name | Corticotropin Releasing Hormone Binding Protein |
| Gene Type | protein-coding |
| Chromosomal Location | 5q13.3 |
| NCBI Gene ID | 1393 ncbi.nlm.nih.gov/gene/1393 |
| Ensembl ID | ENSG00000145715 |
| UniProt ID | P24387 |
| OMIM ID | 122559 |
| HGNC ID | 2356 |
| Aliases | CRF-BP, CRH-BP |
Description
CRHBP encodes a protein that binds corticotropin-releasing hormone (CRH) and inactivates it, thereby modulating the hypothalamic-pituitary-adrenal (HPA) axis and stress response. The protein is secreted and found in plasma, brain, and placenta.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Major Depressive Disorder | Altered CRHBP expression may dysregulate CRH signaling and HPA axis activity | PMID: 25644384 |
| Anxiety Disorders | CRHBP polymorphisms associated with altered stress reactivity | PMID: 20663924 |
| Preterm Birth | CRHBP variants linked to CRH bioavailability and gestational length | PMID: 17903216 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Placenta | 8.3 | Low |
| Liver | 3.1 | Low |
| Adrenal Gland | 2.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y | 15.2 | Neuronal cell line |
| HEK293 | 1.8 | Low expression |
| HepG2 | 0.5 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs10474485 | SNP | 0.15 (MAF) | Intronic, potential regulatory effect |
| rs1875999 | SNP | 0.22 (MAF) | Associated with altered CRHBP expression |
Mutation functional classification
Loss of Function (LOF)
Rare nonsense or frameshift variants predicted to reduce CRH binding capacity
Gain of Function (GOF)
Not reported
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
| • GO:0016918 (GO:0016918) | • GO:0005576 (GO:0005576) |
| • GO:0030424 (GO:0030424) | • GO:0042802 (GO:0042802) |
Pathways
• Corticotropin-releasing hormone signaling pathway (Reactome: R-HSA-375276)
• Neuroactive ligand-receptor interaction (KEGG: hsa04080)
Protein Summary
CRHBP is a 322-amino acid secreted glycoprotein that binds CRH with high affinity, preventing CRH from activating its receptor. It plays a critical role in regulating stress hormone release and is implicated in mood disorders and pregnancy maintenance.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CRHBP Knockout HEK293 Cell Line | EDJ-KQ4345 | Human | 1393 | Details Get a Quote |
| CRHBP Knockout HeLa Cell Line | EDJ-KQ52978 | Human | 1393 | Details Get a Quote |
| CRHBP Knockout A-549 Cell Line | EDJ-KQ61444 | Human | 1393 | Details Get a Quote |
| CRHBP Knockout HCT 116 Cell Line | EDJ-KQ69941 | Human | 1393 | Details Get a Quote |
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