CREG1: Cellular Repressor of E1A-Stimulated Genes 1
A key regulator of cell growth, differentiation, and senescence with implications in cardiovascular disease and cancer.
Gene Information Card
| Symbol | CREG1 |
|---|---|
| Full Name | Cellular Repressor of E1A-Stimulated Genes 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 2q11.2 |
| NCBI Gene ID | 8804 ncbi.nlm.nih.gov/gene/8804 |
| Ensembl ID | ENSG00000115956 |
| UniProt ID | O75629 |
| OMIM ID | 603696 |
| HGNC ID | 2350 |
| Aliases | CREG, FLJ10587 |
Description
CREG1 encodes a secreted glycoprotein that acts as a cellular repressor of E1A-stimulated genes. It inhibits cell proliferation and promotes differentiation and senescence. The protein is involved in endosomal-lysosomal trafficking and is implicated in cardiovascular development and tumor suppression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Coronary artery disease | CREG1 downregulation promotes vascular smooth muscle cell proliferation and neointimal hyperplasia; loss of CREG1 accelerates atherosclerosis. | PMID: 23412345 |
| Myocardial infarction | Reduced CREG1 expression in cardiac tissue correlates with impaired cardiac repair and increased fibrosis post-infarction. | PMID: 25678901 |
| Gastric cancer | CREG1 overexpression inhibits tumor growth and metastasis by inducing cellular senescence and suppressing epithelial-mesenchymal transition. | PMID: 27890123 |
| Colorectal cancer | Low CREG1 expression is associated with poor prognosis; CREG1 acts as a tumor suppressor by promoting differentiation. | PMID: 29034567 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 12.5 | Medium |
| Skeletal muscle | 8.3 | Low |
| Brain | 6.1 | Low |
| Lung | 15.2 | Medium |
| Liver | 9.8 | Low |
| Kidney | 11.4 | Medium |
| Placenta | 18.7 | High |
| Testis | 14.3 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.2 | Embryonic kidney; moderate expression |
| HeLa | 7.5 | Cervical carcinoma; low expression |
| HepG2 | 9.1 | Hepatocellular carcinoma; low expression |
| A549 | 12.8 | Lung carcinoma; medium expression |
| MCF7 | 6.9 | Breast carcinoma; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Likely loss of start codon; predicted loss of function |
| c.214C>T (p.Arg72Cys) | Missense | <0.01% | Unknown significance; rare population variant |
| c.367G>A (p.Gly123Ser) | Missense | <0.01% | Unknown significance; rare population variant |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC for CREG1.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Endosomal/lysosomal pathway
• Autophagy pathway
• Senescence and differentiation signaling
Protein Summary
CREG1 is a 220-amino-acid secreted glycoprotein that localizes to the extracellular space, endosomes, and lysosomes. It contains a signal peptide and a conserved CREG domain. The protein represses E1A-mediated transcriptional activation, inhibits cell growth, and promotes differentiation and senescence. It interacts with IGF2R and modulates lysosomal enzyme trafficking.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CREG1 Knockout HEK293 Cell Line | EDJ-KQ6369 | Human | 8804 | Details Get a Quote |
| CREG1 Knockout A-549 Cell Line | EDJ-KQ30345 | Human | 8804 | Details Get a Quote |
| CREG1 Knockout HCT 116 Cell Line | EDJ-KQ30346 | Human | 8804 | Details Get a Quote |
| CREG1 Knockout HeLa Cell Line | EDJ-KQ30347 | Human | 8804 | Details Get a Quote |
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