CREB5
cAMP Responsive Element Binding Protein 5
Gene Information Card
| Symbol | CREB5 |
|---|---|
| Full Name | cAMP Responsive Element Binding Protein 5 |
| Gene Type | protein-coding |
| Chromosomal Location | 7p15.1 |
| NCBI Gene ID | 9586 ncbi.nlm.nih.gov/gene/9586 |
| Ensembl ID | ENSG00000146592 |
| UniProt ID | Q02930 |
| OMIM ID | 605886 |
| HGNC ID | 16844 |
| Aliases | CREBPA, CREB-5, CRE-BPa |
Description
CREB5 (cAMP Responsive Element Binding Protein 5) encodes a transcription factor that binds to cAMP response elements (CRE) and regulates gene expression in response to cAMP signaling. It is involved in cell proliferation, differentiation, and survival, and has been implicated in various cancers and neurological disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | Overexpression of CREB5 promotes cell proliferation and metastasis via transcriptional activation of target genes. | NCBI Gene, COSMIC |
| Colorectal Cancer | CREB5 amplification and overexpression contribute to tumor progression and poor prognosis. | COSMIC, ClinVar |
| Prostate Cancer | CREB5 upregulation is associated with androgen receptor signaling and disease aggressiveness. | NCBI Gene, OMIM |
| Neuroblastoma | CREB5 expression correlates with tumor differentiation and patient survival. | NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 9.7 | Low |
| Lung | 7.4 | Low |
| Breast | 15.2 | Medium |
| Colon | 18.6 | Medium |
| Prostate | 14.1 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (Breast cancer) | 22.3 | High expression |
| HCT116 (Colorectal cancer) | 19.8 | High expression |
| PC3 (Prostate cancer) | 16.5 | Medium expression |
| SH-SY5Y (Neuroblastoma) | 11.2 | Medium expression |
| HEK293 (Embryonic kidney) | 8.9 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1000C>T (p.Arg334Trp) | Missense | <0.1% | Altered DNA-binding affinity |
| c.1456G>A (p.Glu486Lys) | Missense | <0.1% | Unknown functional impact |
| c.1789_1791del (p.Lys597del) | In-frame deletion | <0.1% | Potential loss of transactivation |
| Amplification | Copy number gain | 1-2% in breast cancer | Increased gene expression |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants in the DNA-binding domain may reduce transcriptional activity.
Gain of Function (GOF)
Gene amplification and overexpression in cancers suggest oncogenic gain-of-function.
Dominant Negative (DN)
Not well characterized; some truncating mutations may interfere with wild-type function.
View complete mutation data：
Gene Ontology (GO)
| • DNA-binding transcription factor activity | • cAMP response element binding |
| • regulation of transcription by RNA polymerase II | • cell differentiation |
| • positive regulation of cell proliferation |
Pathways
• cAMP signaling pathway
• CREB transcription factor pathway
• MAPK signaling pathway
Protein Summary
CREB5 is a 486-amino acid transcription factor containing a basic leucine zipper (bZIP) domain that mediates dimerization and DNA binding. It activates transcription of genes with cAMP response elements (CRE) and plays roles in cellular responses to hormonal and growth factor signals.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CREB5 Knockout HEK293 Cell Line | EDJ-KQ787 | Human | 9586 | Details Get a Quote |
| CREB5 Knockout HeLa Cell Line | EDJ-KQ19497 | Human | 9586 | Details Get a Quote |
| CREB5 Knockout A-549 Cell Line | EDJ-KQ63684 | Human | 9586 | Details Get a Quote |
| CREB5 Knockout HCT 116 Cell Line | EDJ-KQ72146 | Human | 9586 | Details Get a Quote |
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