CRABP2 (Cellular Retinoic Acid Binding Protein 2)
A key intracellular lipid-binding protein involved in retinoic acid signaling, cell differentiation, and cancer progression.
Gene Information Card
| Symbol | CRABP2 |
|---|---|
| Full Name | Cellular Retinoic Acid Binding Protein 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 1q23.1 |
| NCBI Gene ID | 1382 ncbi.nlm.nih.gov/gene/1382 |
| Ensembl ID | ENSG00000143321 |
| UniProt ID | P29373 |
| OMIM ID | 180231 |
| HGNC ID | 2339 |
| Aliases | CRABP-II, RBP6 |
Description
CRABP2 encodes a member of the fatty acid-binding protein (FABP) family, which specifically binds retinoic acid (RA) and transports it to the nucleus. This protein enhances RA-mediated transcriptional activation by delivering RA to retinoic acid receptors (RARs), thereby regulating cell growth, differentiation, and apoptosis. CRABP2 is expressed in various tissues and is implicated in cancer, skin disorders, and developmental processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | CRABP2 overexpression promotes retinoic acid signaling, influencing cell proliferation and differentiation. | ClinVar, COSMIC |
| Non-small cell lung cancer | Altered CRABP2 expression correlates with tumor progression and poor prognosis. | NCBI Gene, COSMIC |
| Skin cancer (melanoma) | CRABP2 modulates retinoic acid-induced differentiation and apoptosis in melanoma cells. | OMIM, ClinVar |
| Endometrial cancer | CRABP2 upregulation is associated with retinoic acid sensitivity and tumor suppression. | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Skin | 12.5 | Medium |
| Breast | 8.3 | Low |
| Lung | 6.1 | Low |
| Endometrium | 15.2 | Medium |
| Adipose tissue | 4.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 18.4 | High expression; retinoic acid responsive |
| A549 (lung cancer) | 9.2 | Moderate expression |
| SK-MEL-28 (melanoma) | 22.1 | High expression; linked to differentiation |
| HEC-1-A (endometrial cancer) | 14.6 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.1% | Potential loss of start codon; effect unknown |
| c.82G>A (p.Gly28Ser) | Missense | <0.1% | Rare variant; clinical significance uncertain |
| c.311C>T (p.Pro104Leu) | Missense | <0.1% | Reported in COSMIC; functional impact unclear |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • retinoic acid binding | • lipid binding |
| • nucleus | • cytoplasm |
| • retinoic acid receptor signaling pathway | • cell differentiation |
| • apoptotic process |
Pathways
• Retinoic acid signaling pathway
• Nuclear receptor transcription pathway
Protein Summary
CRABP2 is a 15.6 kDa intracellular protein that binds all-trans-retinoic acid with high affinity. It shuttles retinoic acid from the cytoplasm to the nucleus, where it facilitates ligand-dependent activation of retinoic acid receptors (RARs). This protein is critical for RA-mediated gene regulation, impacting cell cycle control, differentiation, and apoptosis. CRABP2 expression is tissue-specific and dysregulated in several cancers, where it can modulate response to retinoid-based therapies.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CRABP2 Knockout HEK293 Cell Line | EDJ-KQ4342 | Human | 1382 | Details Get a Quote |
| CRABP2 Knockout A-549 Cell Line | EDJ-KQ26838 | Human | 1382 | Details Get a Quote |
| CRABP2 Knockout HCT 116 Cell Line | EDJ-KQ26839 | Human | 1382 | Details Get a Quote |
| CRABP2 Knockout HeLa Cell Line | EDJ-KQ26840 | Human | 1382 | Details Get a Quote |
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