CPXM1: Carboxypeptidase X, M14 Family Member 1
A metallocarboxypeptidase involved in extracellular matrix remodeling and potential tumor suppression.
Gene Information Card
| Symbol | CPXM1 |
|---|---|
| Full Name | Carboxypeptidase X, M14 Family Member 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 20p13 |
| NCBI Gene ID | 56265 ncbi.nlm.nih.gov/gene/56265 |
| Ensembl ID | ENSG00000101126 |
| UniProt ID | Q9NQW6 |
| OMIM ID | 609536 |
| HGNC ID | 24282 |
| Aliases | CPX-1, CPXM, MGC129606 |
Description
CPXM1 encodes a member of the M14 family of metallocarboxypeptidases. The protein is secreted and may function in extracellular matrix remodeling, cell adhesion, and migration. It is implicated in tumor suppression and neurodevelopmental processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Potential tumor suppressor; reduced expression correlates with metastasis | PMID: 23434518 |
| Gastric cancer | Downregulated; promoter methylation silences expression | PMID: 25689615 |
| Neuroblastoma | Associated with differentiation; expression correlates with favorable outcome | PMID: 21575862 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 5.2 | Low |
| Lung | 3.8 | Low |
| Colon | 2.1 | Low |
| Stomach | 1.5 | Low |
| Testis | 0.9 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.5 | Low expression |
| HeLa | 0.3 | Low expression |
| MCF7 | 0.1 | Not detected |
| A549 | 0.2 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339Trp) | Missense | <0.01% | Unknown; predicted damaging |
| c.1246G>A (p.Gly416Arg) | Missense | <0.01% | Unknown; predicted benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in COSMIC or ClinVar.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • metallocarboxypeptidase activity (GO:0004181) | • extracellular region (GO:0005576) |
| • proteolysis (GO:0006508) | • cell adhesion (GO:0007155) |
| • extracellular matrix organization (GO:0030198) |
Pathways
• Extracellular matrix organization (Reactome: R-HSA-1474244)
• Metalloprotease DUBs (Reactome: R-HSA-5688426)
Protein Summary
CPXM1 is a secreted metallocarboxypeptidase of the M14 family. It contains a signal peptide, a propeptide, and a catalytic domain with a zinc-binding motif. The protein is involved in processing of extracellular peptides and may regulate cell-matrix interactions. Expression is low in most adult tissues but elevated in certain cancers where it may act as a tumor suppressor.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CPXM1 Knockout HEK293 Cell Line | EDJ-KQ3026 | Human | 56265 | Details Get a Quote |
| CPXM1 Knockout HeLa Cell Line | EDJ-KQ56727 | Human | 56265 | Details Get a Quote |
| CPXM1 Knockout A-549 Cell Line | EDJ-KQ65232 | Human | 56265 | Details Get a Quote |
| CPXM1 Knockout HCT 116 Cell Line | EDJ-KQ73671 | Human | 56265 | Details Get a Quote |
