CPO Gene - Carboxypeptidase O
A comprehensive resource on CPO gene, its function, expression, and associated diseases.
Gene Information Card
| Symbol | CPO |
|---|---|
| Full Name | Carboxypeptidase O |
| Gene Type | protein-coding |
| Chromosomal Location | 2q33.1 |
| NCBI Gene ID | 130749 ncbi.nlm.nih.gov/gene/130749 |
| Ensembl ID | ENSG00000162909 |
| UniProt ID | Q8IVL8 |
| OMIM ID | 612726 |
| HGNC ID | 23279 |
| Aliases | CPO-1, MGC138290 |
Description
The CPO gene encodes carboxypeptidase O, a metallocarboxypeptidase that catalyzes the removal of C-terminal basic and hydrophobic amino acids from peptides. It is involved in protein digestion and peptide processing, primarily expressed in the small intestine and colon.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Altered CPO expression may affect peptide hormone processing and tumor microenvironment | NCBI Gene, COSMIC |
| Inflammatory bowel disease | Potential role in peptide metabolism and mucosal homeostasis | NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Small intestine | 45.2 | High |
| Colon | 32.1 | Medium |
| Stomach | 18.7 | Medium |
| Pancreas | 12.3 | Low |
| Liver | 5.6 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Caco-2 | 52.3 | Colorectal adenocarcinoma |
| HT-29 | 38.9 | Colorectal adenocarcinoma |
| HCT 116 | 29.4 | Colorectal carcinoma |
| SW480 | 25.1 | Colorectal adenocarcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1045C>T (p.Arg349Trp) | Missense | <0.01% | Unknown functional impact |
| c.1234G>A (p.Gly412Ser) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in CPO.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in CPO.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported in CPO.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Protein digestion and absorption (Reactome: R-HSA-8963748)
• Peptide hormone metabolism (Reactome: R-HSA-422085)
Protein Summary
Carboxypeptidase O is a secreted metallocarboxypeptidase that removes C-terminal basic and hydrophobic amino acids from peptides. It is highly expressed in the small intestine and colon, where it participates in the final stages of protein digestion and peptide processing. The enzyme requires zinc for catalytic activity and is involved in the metabolism of peptide hormones.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CPO Knockout HEK293 Cell Line | EDJ-KQ9249 | Human | 130749 | Details Get a Quote |
| CPO Knockout HeLa Cell Line | EDJ-KQ58282 | Human | 130749 | Details Get a Quote |
| CPO Knockout A-549 Cell Line | EDJ-KQ66772 | Human | 130749 | Details Get a Quote |
| CPO Knockout HCT 116 Cell Line | EDJ-KQ75175 | Human | 130749 | Details Get a Quote |
