CPM (Carboxypeptidase M) Gene
A comprehensive overview of the CPM gene, its function, expression, and associated diseases.
Gene Information Card
| Symbol | CPM |
|---|---|
| Full Name | Carboxypeptidase M |
| Gene Type | protein-coding |
| Chromosomal Location | 12q14.3 |
| NCBI Gene ID | 1368 ncbi.nlm.nih.gov/gene/1368 |
| Ensembl ID | ENSG00000135678 |
| UniProt ID | P14384 |
| OMIM ID | 114860 |
| HGNC ID | 2312 |
| Aliases | CPM-1, carboxypeptidase M |
Description
The CPM gene encodes carboxypeptidase M, a membrane-bound zinc-dependent metalloprotease that cleaves C-terminal basic amino acids (arginine or lysine) from peptides and proteins. It is involved in the regulation of peptide hormone activity, kinin metabolism, and inflammatory responses. The enzyme is anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage and is widely expressed in various tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | CPM expression is altered, potentially affecting tumor microenvironment via peptide processing | NCBI Gene, COSMIC |
| Lung cancer | CPM overexpression may influence cell migration and invasion | COSMIC, NCBI Gene |
| Inflammatory disorders | CPM modulates bradykinin and anaphylatoxin activity, impacting inflammation | UniProt, OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 22.3 | Medium |
| Kidney | 18.7 | Medium |
| Small intestine | 15.1 | Medium |
| Brain | 8.2 | Low |
| Heart | 6.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung) | 25.4 | High expression |
| HEK 293 (embryonic kidney) | 20.1 | Medium expression |
| HepG2 (liver) | 12.3 | Low expression |
| MCF7 (breast) | 9.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.104C>T (p.Thr35Met) | missense | <0.01% | Unknown functional impact |
| c.457G>A (p.Val153Ile) | missense | <0.01% | Unknown functional impact |
| c.788A>G (p.Asn263Ser) | missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • metallocarboxypeptidase activity (GO:0004181) | • proteolysis (GO:0006508) |
| • plasma membrane (GO:0005886) | • identical protein binding (GO:0042802) |
| • metallopeptidase activity (GO:0008237) |
Pathways
• hsa04080 - Neuroactive ligand-receptor interaction
• hsa04610 - Complement and coagulation cascades
• hsa05200 - Pathways in cancer
Protein Summary
Carboxypeptidase M (CPM) is a 440-amino-acid glycoprotein anchored to the cell membrane via GPI linkage. It functions as a zinc-dependent exopeptidase, preferentially removing C-terminal arginine or lysine residues. CPM plays roles in peptide hormone processing (e.g., bradykinin, anaphylatoxins) and may influence cancer progression through modulation of the extracellular peptide milieu.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CPM Knockout HEK293 Cell Line | EDJ-KQ12995 | Human | 1368 | Details Get a Quote |
| CPM Knockout A-549 Cell Line | EDJ-KQ42238 | Human | 1368 | Details Get a Quote |
| CPM Knockout HCT 116 Cell Line | EDJ-KQ42239 | Human | 1368 | Details Get a Quote |
| CPM Knockout HeLa Cell Line | EDJ-KQ42240 | Human | 1368 | Details Get a Quote |
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