CPEB2
Cytoplasmic polyadenylation element binding protein 2
Gene Information Card
| Symbol | CPEB2 |
|---|---|
| Full Name | Cytoplasmic polyadenylation element binding protein 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 4p15.33 |
| NCBI Gene ID | 132864 ncbi.nlm.nih.gov/gene/132864 |
| Ensembl ID | ENSG00000138684 |
| UniProt ID | Q7Z5Q1 |
| OMIM ID | 610606 |
| HGNC ID | 21745 |
| Aliases | CPEB-2, KIAA1778 |
Description
CPEB2 encodes a member of the cytoplasmic polyadenylation element binding protein family. This RNA-binding protein regulates translation by binding to cytoplasmic polyadenylation elements (CPEs) in the 3' UTR of target mRNAs, controlling polyadenylation-induced translation. CPEB2 is involved in cell cycle progression, synaptic plasticity, and germ cell development. Alternative splicing generates multiple transcript variants.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | CPEB2 overexpression correlates with poor prognosis; may promote tumor growth via translational regulation of oncogenic mRNAs | PMID: 25636800 |
| Gastric cancer | CPEB2 upregulation associated with metastasis and reduced survival; modulates EMT-related gene expression | PMID: 29187738 |
| Ovarian cancer | CPEB2 expression linked to chemoresistance and stemness; regulates translation of pluripotency factors | PMID: 30356048 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Testis | 8.3 | Medium |
| Breast | 6.1 | Low |
| Ovary | 5.4 | Low |
| Stomach | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 10.2 | Moderate expression |
| HeLa (cervical cancer) | 9.1 | Moderate expression |
| A549 (lung cancer) | 7.5 | Low expression |
| K562 (leukemia) | 3.4 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1012C>T (p.Arg338Trp) | Missense | <0.01% (gnomAD) | Unknown functional effect; rare variant |
| c.1456G>A (p.Gly486Ser) | Missense | <0.01% (gnomAD) | Unknown functional effect; rare variant |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in CPEB2.
Gain of Function (GOF)
No well-characterized gain-of-function mutations reported in CPEB2.
Dominant Negative (DN)
No well-characterized dominant-negative mutations reported in CPEB2.
View complete mutation data：
Gene Ontology (GO)
| • RNA binding | • mRNA 3'-UTR binding |
| • cytoplasmic polyadenylation element binding | • regulation of translation |
| • positive regulation of translation | • cytoplasm |
| • P-body |
Pathways
• Cytoplasmic polyadenylation element binding protein (CPEB) pathway
• Translational regulation by CPEB
Protein Summary
CPEB2 is a 554-amino acid RNA-binding protein containing two N-terminal RNA recognition motifs (RRMs) and a C-terminal zinc finger domain. It binds specifically to cytoplasmic polyadenylation elements (CPEs) in the 3' UTR of target mRNAs, promoting polyadenylation and translational activation. CPEB2 is predominantly cytoplasmic and shuttles between the cytoplasm and nucleus. It plays roles in cell cycle control, synaptic plasticity, and germline development. Post-translational modifications include phosphorylation, which modulates its activity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CPEB2 Knockout HEK293 Cell Line | EDJ-KQ9305 | Human | 132864 | Details Get a Quote |
| CPEB2 Knockout A-549 Cell Line | EDJ-KQ35919 | Human | 132864 | Details Get a Quote |
| CPEB2 Knockout HCT 116 Cell Line | EDJ-KQ35920 | Human | 132864 | Details Get a Quote |
| CPEB2 Knockout HeLa Cell Line | EDJ-KQ35921 | Human | 132864 | Details Get a Quote |
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