CORT Gene - Cortistatin
Comprehensive gene information for CORT (cortistatin) from NCBI, Ensembl, UniProt, OMIM, HGNC, COSMIC, and ClinVar.
Gene Information Card
| Symbol | CORT |
|---|---|
| Full Name | cortistatin |
| Gene Type | protein-coding |
| Chromosomal Location | 1p36.22 |
| NCBI Gene ID | 1325 ncbi.nlm.nih.gov/gene/1325 |
| Ensembl ID | ENSG00000141574 |
| UniProt ID | O00230 |
| OMIM ID | 602484 |
| HGNC ID | 2255 |
| Aliases | CST, cortistatin-14, cortistatin-17, cortistatin-29 |
Description
The CORT gene encodes cortistatin, a neuropeptide structurally related to somatostatin. It is expressed primarily in the central nervous system and immune cells, where it modulates neurotransmission, sleep regulation, and immune responses. Cortistatin binds to somatostatin receptors (SSTR1-5) and has distinct anti-inflammatory and neuroprotective properties.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Alzheimer's disease | Cortistatin levels are altered in brain regions affected by Alzheimer's; potential neuroprotective role through modulation of inflammation and synaptic activity. | PMID: 19013282 |
| Inflammatory bowel disease | Cortistatin reduces intestinal inflammation by inhibiting pro-inflammatory cytokine release and promoting regulatory T cell activity. | PMID: 17086103 |
| Rheumatoid arthritis | Cortistatin suppresses synovial inflammation and joint destruction in experimental models via somatostatin receptor activation. | PMID: 19155507 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain (cerebral cortex) | 0.8 | Low |
| Brain (hippocampus) | 1.2 | Low |
| Lymph node | 0.3 | Not detected |
| Spleen | 0.2 | Not detected |
| Testis | 0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 0.5 | Low expression |
| Jurkat (T-cell leukemia) | 0.1 | Not detected |
| HeLa (cervical carcinoma) | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.01% | Likely loss of start codon; predicted loss of function |
| c.214C>T (p.Arg72Cys) | missense | <0.01% | Unknown significance; rare variant |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
Pathways
• REACT:1474221 (Somatostatin receptor signaling)
• REACT:1474223 (GPCR ligand binding)
Protein Summary
Cortistatin is a 14-29 amino acid neuropeptide (depending on isoform) that shares structural homology with somatostatin. It is produced as a preproprotein and cleaved to generate mature peptides. Cortistatin binds all five somatostatin receptors (SSTR1-5) and exhibits anti-inflammatory, neuroprotective, and sleep-modulating activities. It is predominantly expressed in the brain and immune cells.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CORT Knockout HEK293 Cell Line | EDJ-KQ50202 | Human | 1325 | Details Get a Quote |
| CENPS-CORT Knockout HEK293 Cell Line | EDJ-KQ52471 | Human | 100526739 | Details Get a Quote |
| CORT Knockout HeLa Cell Line | EDJ-KQ52960 | Human | 1325 | Details Get a Quote |
| CENPS-CORT Knockout HeLa Cell Line | EDJ-KQ60934 | Human | 100526739 | Details Get a Quote |
| CORT Knockout A-549 Cell Line | EDJ-KQ61427 | Human | 1325 | Details Get a Quote |
| CENPS-CORT Knockout A-549 Cell Line | EDJ-KQ69409 | Human | 100526739 | Details Get a Quote |
| CORT Knockout HCT 116 Cell Line | EDJ-KQ69924 | Human | 1325 | Details Get a Quote |
| CENPS-CORT Knockout HCT 116 Cell Line | EDJ-KQ77760 | Human | 100526739 | Details Get a Quote |
