CORO2B
Coronin 2B: Actin-binding protein involved in cell motility and cytoskeletal dynamics
Gene Information Card
| Symbol | CORO2B |
|---|---|
| Full Name | coronin 2B |
| Gene Type | protein-coding |
| Chromosomal Location | 15q23 |
| NCBI Gene ID | 10391 ncbi.nlm.nih.gov/gene/10391 |
| Ensembl ID | ENSG00000137877 |
| UniProt ID | Q9C0H2 |
| OMIM ID | 609900 |
| HGNC ID | 2256 |
| Aliases | CORO2B, coronin-2B, CLIPINB, coronin-like protein B |
Description
CORO2B encodes coronin 2B, a member of the coronin family of actin-binding proteins. It is involved in regulating actin cytoskeleton dynamics, cell motility, and endocytosis. The protein contains WD40 repeats and a coiled-coil domain, localizing to the cell cortex and lamellipodia.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Altered expression may affect cell migration and invasion | COSMIC; literature |
| Neurodegenerative disorders | Potential role in cytoskeletal dysfunction | Literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 10.2 | Medium |
| Lung | 8.5 | Medium |
| Heart | 6.1 | Low |
| Liver | 4.3 | Low |
| Kidney | 7.8 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 12.5 | Moderate expression |
| HEK293 | 9.8 | Moderate expression |
| SH-SY5Y | 15.3 | Higher expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234G>A | missense | <0.1% | Unknown |
| c.567_568del | frameshift | <0.1% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations predicted to truncate protein and disrupt actin binding
Gain of Function (GOF)
Not reported
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
| • actin binding | • cytoskeleton |
| • cell cortex | • lamellipodium |
| • endocytosis |
Pathways
• Actin cytoskeleton regulation
• Cell migration
Protein Summary
Coronin 2B is a 480-amino acid protein with WD40 repeats and a coiled-coil domain. It binds F-actin and localizes to dynamic actin structures, modulating cell shape and movement.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CORO2B Knockout HEK293 Cell Line | EDJ-KQ7030 | Human | 10391 | Details Get a Quote |
| CORO2B Knockout A-549 Cell Line | EDJ-KQ31783 | Human | 10391 | Details Get a Quote |
| CORO2B Knockout HCT 116 Cell Line | EDJ-KQ31784 | Human | 10391 | Details Get a Quote |
| CORO2B Knockout HeLa Cell Line | EDJ-KQ31785 | Human | 10391 | Details Get a Quote |
