CORO1C
Coronin 1C
Gene Information Card
| Symbol | CORO1C |
|---|---|
| Full Name | Coronin 1C |
| Gene Type | Protein coding |
| Chromosomal Location | 12q24.11 |
| NCBI Gene ID | 23603 ncbi.nlm.nih.gov/gene/23603 |
| Ensembl ID | ENSG00000110848 |
| UniProt ID | Q9ULV4 |
| OMIM ID | 609010 |
| HGNC ID | 2252 |
| Aliases | CORO1C, coronin-1C, coronin 3, CRN4, hCRN4 |
Description
CORO1C encodes coronin 1C, a member of the coronin family of actin-binding proteins. It regulates actin cytoskeleton dynamics, cell motility, and endocytosis. Overexpression is linked to cancer cell invasion and metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression promotes cell migration and invasion via actin remodeling | PMID: 23431147 |
| Gastric cancer | Upregulation correlates with poor prognosis and metastasis | PMID: 27358096 |
| Glioblastoma | CORO1C silencing reduces tumor cell motility | PMID: 25605248 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 16.2 | Medium |
| Breast | 12.8 | Medium |
| Brain | 8.5 | Low |
| Liver | 6.3 | Low |
| Kidney | 10.1 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 | 14.5 | Breast cancer cell line |
| A549 | 18.3 | Lung cancer cell line |
| U87MG | 11.2 | Glioblastoma cell line |
| HEK293 | 9.8 | Embryonic kidney cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Ile) | Missense | <0.01% | Unknown functional impact |
| c.457G>A (p.Glu153Lys) | Missense | <0.01% | Reported in COSMIC |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; rare truncating variants may reduce actin binding.
Gain of Function (GOF)
Overexpression in cancers suggests potential gain-of-function in cell migration.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • actin binding | • actin cytoskeleton organization |
| • cell migration | • endocytosis |
| • protein homodimerization activity |
Pathways
• Regulation of actin cytoskeleton
• Fc gamma R-mediated phagocytosis
• Chemokine signaling pathway
Protein Summary
Coronin 1C is a 474-amino acid protein containing a WD40 repeat domain and a coiled-coil region. It binds F-actin and regulates actin dynamics, cell protrusion, and vesicle trafficking. It is widely expressed and implicated in cancer progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CORO1C Knockout HEK293 Cell Line | EDJ-KQ3033 | Human | 23603 | Details Get a Quote |
| CORO1C Knockout A-549 Cell Line | EDJ-KQ24263 | Human | 23603 | Details Get a Quote |
| CORO1C Knockout HCT 116 Cell Line | EDJ-KQ24264 | Human | 23603 | Details Get a Quote |
| CORO1C Knockout HeLa Cell Line | EDJ-KQ24265 | Human | 23603 | Details Get a Quote |
