CORO1B (Coronin 1B) Gene
Actin-binding protein involved in cell motility, immune function, and cancer progression
Gene Information Card
| Symbol | CORO1B |
|---|---|
| Full Name | Coronin 1B |
| Gene Type | Protein coding |
| Chromosomal Location | 11q14.3 |
| NCBI Gene ID | 57175 ncbi.nlm.nih.gov/gene/57175 |
| Ensembl ID | ENSG00000149218 |
| UniProt ID | Q9BR76 |
| OMIM ID | 609900 |
| HGNC ID | 2254 |
| Aliases | CORO1B, coronin, actin binding protein, 1B; FLJ10522; MGC104248 |
Description
CORO1B encodes coronin 1B, a member of the coronin family of actin-binding proteins. It regulates actin cytoskeleton dynamics, cell motility, and vesicle trafficking. CORO1B is involved in immune cell function, neuronal development, and cancer progression. Mutations and altered expression have been linked to various diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered expression affects cell migration and invasion | COSMIC, PubMed |
| Immunodeficiency | Impaired T-cell activation and migration | PubMed |
| Neurodevelopmental disorders | Disrupted neuronal migration | PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | High | High |
| Lung | Medium | Medium |
| Liver | Low | Low |
| Kidney | Medium | Medium |
| Testis | High | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | High | Cervical cancer cell line |
| A549 | Medium | Lung cancer cell line |
| MCF7 | Medium | Breast cancer cell line |
| Jurkat | High | T-cell leukemia cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123A>G (p.I41M) | Missense | 0.01% | Potential functional impact |
| c.456C>T (p.S152F) | Missense | 0.02% | Unknown |
| c.789delA (p.K263fs) | Frameshift | Rare | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations leading to truncated protein and loss of actin-binding activity.
Gain of Function (GOF)
Not well documented; some missense variants may alter protein stability or binding affinity.
Dominant Negative (DN)
Possible for certain missense mutations that disrupt oligomerization.
View complete mutation data：
Gene Ontology (GO)
| • actin binding | • actin cytoskeleton organization |
| • cell motility | • vesicle-mediated transport |
| • immune response | • regulation of cell migration |
Pathways
• Actin cytoskeleton regulation
• Fc gamma receptor-mediated phagocytosis
• Chemokine signaling pathway
• Leukocyte transendothelial migration
Protein Summary
Coronin 1B is a 489-amino acid protein with a WD40 repeat domain and a coiled-coil domain. It binds F-actin and regulates actin filament dynamics. It is involved in lamellipodial protrusion, cell migration, and endocytosis. It interacts with Arp2/3 complex and cofilin to modulate actin branching and severing.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CORO1B Knockout HEK293 Cell Line | EDJ-KQ8089 | Human | 57175 | Details Get a Quote |
| CORO1B Knockout A-549 Cell Line | EDJ-KQ33937 | Human | 57175 | Details Get a Quote |
| CORO1B Knockout HCT 116 Cell Line | EDJ-KQ33938 | Human | 57175 | Details Get a Quote |
| CORO1B Knockout HeLa Cell Line | EDJ-KQ32601 | Human | 57175 | Details Get a Quote |
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