CORIN
Corin, Serine Peptidase
Gene Information Card
| Symbol | CORIN |
|---|---|
| Full Name | Corin, Serine Peptidase |
| Gene Type | protein-coding |
| Chromosomal Location | 4p12 |
| NCBI Gene ID | 10699 ncbi.nlm.nih.gov/gene/10699 |
| Ensembl ID | ENSG00000145244 |
| UniProt ID | Q9Y5Q5 |
| OMIM ID | 605236 |
| HGNC ID | 2332 |
| Aliases | ATRNP, Lrp4, corin |
Description
CORIN encodes a transmembrane serine protease that converts pro-atrial natriuretic peptide (pro-ANP) to active ANP, regulating blood pressure and cardiac function. It is expressed primarily in the heart and also in other tissues. Mutations in CORIN are associated with hypertension, preeclampsia, and cardiac hypertrophy.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hypertension | Loss of corin activity reduces ANP activation, impairing natriuresis and vasodilation. | PMID: 22923420 |
| Preeclampsia | Decreased corin expression in placenta leads to impaired ANP processing and hypertensive complications. | PMID: 20884846 |
| Cardiac hypertrophy | Reduced corin activity contributes to cardiac remodeling via altered natriuretic peptide signaling. | PMID: 22923420 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 25.6 | High |
| Kidney | 4.3 | Low |
| Liver | 1.2 | Not detected |
| Lung | 2.8 | Low |
| Placenta | 8.9 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Cardiomyocytes (AC16) | 15.2 | High expression |
| HEK293 | 0.5 | Very low |
| HepG2 | 0.3 | Not detected |
| BeWo (placental) | 12.1 | Moderate |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1730C>T (p.Thr577Ile) | Missense | 0.001 | Reduced pro-ANP processing activity |
| c.2149G>A (p.Gly717Arg) | Missense | 0.0005 | Impaired corin activation |
| c.2869C>T (p.Arg957Cys) | Missense | 0.0002 | Decreased cell surface expression |
Mutation functional classification
Loss of Function (LOF)
Missense mutations (e.g., p.Thr577Ile) reduce corin's catalytic activity or cell surface expression, impairing ANP activation.
Gain of Function (GOF)
No gain-of-function mutations reported in CORIN.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Atrial natriuretic peptide (ANP) signaling pathway
• Regulation of blood pressure by natriuretic peptides
Protein Summary
Corin is a 1042-amino-acid transmembrane serine protease with a cytoplasmic domain, transmembrane region, and an extracellular protease domain. It is synthesized as a zymogen and activated by proteolytic cleavage. Corin specifically cleaves pro-ANP to generate active ANP, which promotes natriuresis, vasodilation, and blood pressure reduction. The protein is expressed on the surface of cardiomyocytes and in other tissues including placenta and kidney.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CORIN Knockout HEK293 Cell Line | EDJ-KQ6504 | Human | 10699 | Details Get a Quote |
| CORIN Knockout HCT 116 Cell Line | EDJ-KQ32024 | Human | 10699 | Details Get a Quote |
| CORIN Knockout HeLa Cell Line | EDJ-KQ55466 | Human | 10699 | Details Get a Quote |
| CORIN Knockout A-549 Cell Line | EDJ-KQ63951 | Human | 10699 | Details Get a Quote |
