COPG2
COPI Coat Complex Subunit Gamma 2
Gene Information Card
| Symbol | COPG2 |
|---|---|
| Full Name | COPI Coat Complex Subunit Gamma 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 7q32.2 |
| NCBI Gene ID | 26958 ncbi.nlm.nih.gov/gene/26958 |
| Ensembl ID | ENSG00000106344 |
| UniProt ID | Q9UBF2 |
| OMIM ID | 604355 |
| HGNC ID | 2237 |
| Aliases | gamma-2-COP, COPG, COPG2, gamma2-COP |
Description
COPG2 encodes the gamma-2 subunit of the coatomer protein complex I (COPI), which is involved in retrograde vesicle transport from the Golgi apparatus to the endoplasmic reticulum. The COPI complex is essential for maintaining Golgi structure and function, and COPG2 specifically contributes to cargo recognition and vesicle coat assembly.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | No curated disease entries in ClinVar or OMIM as of current data |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Liver | 8.3 | Low |
| Kidney | 10.1 | Medium |
| Heart | 7.6 | Low |
| Lung | 9.4 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 14.2 | Moderate expression |
| HEK293 | 11.8 | Moderate expression |
| K562 | 9.5 | Low expression |
| HepG2 | 10.3 | Medium expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Cys) | Missense | <0.01% | Unknown functional impact |
| c.567G>A (p.Val189Ile) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in COPG2.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in COPG2.
Dominant Negative (DN)
No dominant-negative mutations reported in COPG2.
View complete mutation data：
Gene Ontology (GO)
| • protein transport | • Golgi vesicle transport |
| • COPI vesicle coat | • intracellular protein transport |
| • membrane docking |
Pathways
• COPI-dependent Golgi-to-ER retrograde traffic
• Vesicle-mediated transport
Protein Summary
COPG2 is a 874-amino-acid protein that forms part of the COPI coatomer complex. It contains a WD40 repeat domain and interacts with other coatomer subunits to mediate vesicle budding and cargo selection. The protein is ubiquitously expressed and localizes to the Golgi apparatus.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| COPG2 Knockout HEK293 Cell Line | EDJ-KQ8627 | Human | 26958 | Details Get a Quote |
| COPG2 Knockout A-549 Cell Line | EDJ-KQ34784 | Human | 26958 | Details Get a Quote |
| COPG2 Knockout HCT 116 Cell Line | EDJ-KQ34785 | Human | 26958 | Details Get a Quote |
| COPG2 Knockout HeLa Cell Line | EDJ-KQ34786 | Human | 26958 | Details Get a Quote |
