CNRIP1
Cannabinoid Receptor Interacting Protein 1
Gene Information Card
| Symbol | CNRIP1 |
|---|---|
| Full Name | cannabinoid receptor interacting protein 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 2p23.3 |
| NCBI Gene ID | 25927 ncbi.nlm.nih.gov/gene/25927 |
| Ensembl ID | ENSG00000115970 |
| UniProt ID | Q96F85 |
| OMIM ID | 609539 |
| HGNC ID | 24543 |
| Aliases | C2orf23, FLJ20186, MGC138499 |
Description
CNRIP1 encodes a protein that interacts with the cannabinoid receptor 1 (CB1) and modulates its signaling. The protein is involved in regulating G-protein coupled receptor activity and may play a role in neuronal function and synaptic transmission. CNRIP1 is expressed in brain tissues and is implicated in cannabinoid-related pathways.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Schizophrenia | Altered CNRIP1 expression may affect CB1 receptor signaling in the brain, contributing to neuropsychiatric symptoms. | PMID: 20628086 |
| Substance Use Disorders | CNRIP1 modulates cannabinoid receptor activity, potentially influencing addiction pathways. | PMID: 21943603 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain (cerebral cortex) | 12.3 | Medium |
| Cerebellum | 8.7 | Low |
| Testis | 6.1 | Low |
| Heart | 2.4 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 15.2 | Neuronal model |
| HEK293 (embryonic kidney) | 3.8 | Low expression |
| U-87 MG (glioblastoma) | 10.5 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.344G>A (p.Arg115His) | Missense | <0.01% | Unknown functional impact |
| c.527C>T (p.Pro176Leu) | Missense | <0.01% | Predicted benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in CNRIP1.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor binding (GO:0001664) | • cannabinoid receptor activity (GO:0004949) |
| • plasma membrane (GO:0005886) | • synapse (GO:0045202) |
Pathways
• Cannabinoid receptor signaling (Reactome:R-HSA-416476)
• GPCR downstream signaling (Reactome:R-HSA-388396)
Protein Summary
CNRIP1 is a 164-amino acid protein that interacts with the C-terminal tail of the cannabinoid receptor 1 (CB1). It is localized to the plasma membrane and synaptic regions, where it modulates CB1 receptor internalization and signaling. The protein is predominantly expressed in the brain and is involved in regulating endocannabinoid system activity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CNRIP1 Knockout HEK293 Cell Line | EDJ-KQ8311 | Human | 25927 | Details Get a Quote |
| CNRIP1 Knockout HeLa Cell Line | EDJ-KQ34283 | Human | 25927 | Details Get a Quote |
| CNRIP1 Knockout A-549 Cell Line | EDJ-KQ64341 | Human | 25927 | Details Get a Quote |
| CNRIP1 Knockout HCT 116 Cell Line | EDJ-KQ72794 | Human | 25927 | Details Get a Quote |
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