CNOT11
CCR4-NOT Transcription Complex Subunit 11
Gene Information Card
| Symbol | CNOT11 |
|---|---|
| Full Name | CCR4-NOT transcription complex subunit 11 |
| Gene Type | protein-coding |
| Chromosomal Location | 2q33.3 |
| NCBI Gene ID | 55571 ncbi.nlm.nih.gov/gene/55571 |
| Ensembl ID | ENSG00000115956 |
| UniProt ID | Q9UKZ1 |
| OMIM ID | 615472 |
| HGNC ID | 20323 |
| Aliases | C2orf29, HSPC085, NOT11 |
Description
CNOT11 encodes a subunit of the CCR4-NOT complex, a major regulator of mRNA synthesis and decay. The complex is involved in transcription initiation, elongation, and mRNA degradation. CNOT11 specifically interacts with other subunits to modulate gene expression and is implicated in cellular processes including cell cycle control and differentiation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No curated evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lymph node | 8.2 | Low |
| Brain | 6.1 | Low |
| Liver | 5.3 | Low |
| Kidney | 4.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.1 | Embryonic kidney cells |
| HeLa | 8.7 | Cervical cancer cells |
| K562 | 7.4 | Leukemia cells |
| HepG2 | 6.8 | Hepatocellular carcinoma cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown effect |
| c.100C>T | synonymous | <0.01% | No amino acid change |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • CCR4-NOT complex (GO:0030014) |
| • magnesium ion binding (GO:0000287) | • RNA binding (GO:0003723) |
Pathways
• mRNA surveillance pathway (Reactome: R-HSA-72163)
• Deadenylation-dependent mRNA decay (Reactome: R-HSA-429947)
Protein Summary
CNOT11 is a 54 kDa protein that localizes to the nucleus and cytoplasm. It contains a NOT-box domain and interacts with CNOT1 and CNOT10 to form a subcomplex within the CCR4-NOT complex. The protein is involved in deadenylation and subsequent degradation of mRNA, thereby regulating gene expression post-transcriptionally.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CNOT11 Knockout HEK293 Cell Line | EDJ-KQ12964 | Human | 55571 | Details Get a Quote |
| CNOT11 Knockout A-549 Cell Line | EDJ-KQ40933 | Human | 55571 | Details Get a Quote |
| CNOT11 Knockout HCT 116 Cell Line | EDJ-KQ42179 | Human | 55571 | Details Get a Quote |
| CNOT11 Knockout HeLa Cell Line | EDJ-KQ42180 | Human | 55571 | Details Get a Quote |
