CLPSL2
Colipase-like 2
Gene Information Card
| Symbol | CLPSL2 |
|---|---|
| Full Name | colipase-like 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 6p21.1 |
| NCBI Gene ID | 100506658 ncbi.nlm.nih.gov/gene/100506658 |
| Ensembl ID | ENSG00000204301 |
| UniProt ID | A6NKD9 |
| OMIM ID | 617472 |
| HGNC ID | 37244 |
| Aliases | CLPSL2, dJ1009E9.1 |
Description
CLPSL2 (colipase-like 2) is a protein-coding gene located on chromosome 6p21.1. It encodes a protein with similarity to colipase, a cofactor required for efficient dietary fat digestion by pancreatic lipase. The specific biological function of CLPSL2 remains under investigation, but it is predicted to be involved in lipid metabolism. Expression data suggest low to moderate levels in select tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease association reported | Not applicable | No evidence in ClinVar, OMIM, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 2.3 | Low |
| Adipose tissue | 1.1 | Low |
| Liver | 0.8 | Not detected |
| Pancreas | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.2 | Low expression |
| HepG2 | 0.1 | Not detected |
| K562 | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported variants | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Protein Summary
The CLPSL2 protein (UniProt A6NKD9) is a predicted secreted protein with a colipase-like domain. Its exact physiological role is not yet characterized, but it may participate in lipid digestion or transport. No functional studies or disease associations have been reported.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CLPSL2 Knockout HEK293 Cell Line | EDJ-KQ12192 | Human | 389383 | Details Get a Quote |
| CLPSL2 Knockout HeLa Cell Line | EDJ-KQ60082 | Human | 389383 | Details Get a Quote |
| CLPSL2 Knockout A-549 Cell Line | EDJ-KQ68546 | Human | 389383 | Details Get a Quote |
| CLPSL2 Knockout HCT 116 Cell Line | EDJ-KQ76921 | Human | 389383 | Details Get a Quote |
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