CLPSL1: Colipase-Like 1 – A Pseudogene with Potential Regulatory Roles
Explore the genomic context, expression patterns, and clinical significance of CLPSL1, a colipase-like pseudogene on chromosome 6.
Gene Information Card
| Symbol | CLPSL1 |
|---|---|
| Full Name | colipase-like 1 |
| Gene Type | pseudogene |
| Chromosomal Location | 6p21.1 |
| NCBI Gene ID | 340596 ncbi.nlm.nih.gov/gene/340596 |
| Ensembl ID | ENSG00000204356 |
| UniProt ID | None (pseudogene) |
| OMIM ID | None |
| HGNC ID | 28035 |
| Aliases | CLPSL, dJ402H5.2 |
Description
CLPSL1 (colipase-like 1) is a pseudogene located on chromosome 6 at position p21.1. It is part of the colipase gene family, which includes the functional CLPS gene. As a pseudogene, CLPSL1 has lost its protein-coding capacity due to the presence of premature stop codons or frameshift mutations. However, it may still be transcribed into RNA and could play regulatory roles, such as acting as a microRNA sponge or a source of small interfering RNAs. The genomic region of CLPSL1 is within the major histocompatibility complex (MHC) class III region, which is associated with immune function and various diseases. Despite being a pseudogene, CLPSL1 expression has been detected in certain tissues, suggesting potential functional relevance.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No direct disease association | As a pseudogene, CLPSL1 is not known to encode a functional protein. However, its genomic location in the MHC region may link it to immune-related disorders, but no direct evidence exists. | No direct evidence from ClinVar or OMIM. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.0 | Not expressed |
| Kidney | 0.0 | Not expressed |
| Liver | 0.0 | Not expressed |
| Brain | 0.0 | Not expressed |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 0.0 | No expression detected |
| A549 | 0.0 | No expression detected |
| MCF7 | 0.0 | No expression detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
Not applicable – pseudogene with no protein product.
Gain of Function (GOF)
Not applicable – pseudogene with no protein product.
Dominant Negative (DN)
Not applicable – pseudogene with no protein product.
View complete mutation data：
Protein Summary
CLPSL1 is a pseudogene and does not produce a functional protein. It is a non-coding RNA locus that may have regulatory functions, but no protein product has been identified. The gene is located in a gene-dense region on chromosome 6, and its transcription may be incidental or regulatory.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CLPSL1 Knockout HEK293 Cell Line | EDJ-KQ12950 | Human | 340204 | Details Get a Quote |
| CLPSL1 Knockout HeLa Cell Line | EDJ-KQ59670 | Human | 340204 | Details Get a Quote |
| CLPSL1 Knockout A-549 Cell Line | EDJ-KQ68142 | Human | 340204 | Details Get a Quote |
| CLPSL1 Knockout HCT 116 Cell Line | EDJ-KQ76519 | Human | 340204 | Details Get a Quote |
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